New targets for resolution of airway remodeling in obstructive lung diseases.

Authors

Ajay P. Nayak, Thomas Jefferson UniversityFollow
Deepak A. Deshpande, Thomas Jefferson UniversityFollow
Raymond B. Penn, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

5-30-2018

Comments

This article has been peer reviewed. It is the author’s final published version in F1000Research, Volume 7, May 2018, Article number 680.

The published version is available at https://doi.org/10.12688/f1000research.14581.1. Copyright © Penn et al.

Abstract

Airway remodeling (AR) is a progressive pathological feature of the obstructive lung diseases, including asthma and chronic obstructive pulmonary disease (COPD). The pathology manifests itself in the form of significant, progressive, and (to date) seemingly irreversible changes to distinct respiratory structural compartments. Consequently, AR correlates with disease severity and the gradual decline in pulmonary function associated with asthma and COPD. Although current asthma/COPD drugs manage airway contraction and inflammation, none of these effectively prevent or reverse features of AR. In this review, we provide a brief overview of the features and putative mechanisms affecting AR. We further discuss recently proposed strategies with promise for deterring or treating AR.

Recommended Citation

Nayak, Ajay P.; Deshpande, Deepak A.; and Penn, Raymond B., "New targets for resolution of airway remodeling in obstructive lung diseases." (2018). Center for Translational Medicine Faculty Papers. Paper 48.
https://jdc.jefferson.edu/transmedfp/48

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

29904584

Language

English