The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease.

Authors

Elena Mogilyansky, Thomas Jefferson UniversityFollow
Isidore Rigoutsos, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

12-1-2013

Comments

This article has been peer reviewed. It was published in: Cell Death and Differentiation

Volume 20, Issue 12, December 2013, Pages 1603-1614.

The published version is available at DOI: 10.1038/cdd.2013.125 . Copyright © Nature

Abstract

The miR-17/92 cluster is among the best-studied microRNA clusters. Interest in the cluster and its members has been increasing steadily and the number of publications has grown exponentially since its discovery with more than 1000 articles published in 2012 alone. Originally found to be involved in tumorigenesis, research work in recent years has uncovered unexpected roles for its members in a wide variety of settings that include normal development, immune diseases, cardiovascular diseases, neurodegenerative diseases and aging. In light of its ever-increasing importance and ever-widening regulatory roles, we review here the latest body of knowledge on the cluster's involvement in health and disease as well as provide a novel perspective on the full spectrum of protein-coding and non-coding transcripts that are likely regulated by its members.

Recommended Citation

Mogilyansky, Elena and Rigoutsos, Isidore, "The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease." (2013). Computational Medicine Center Faculty Papers. Paper 2.
https://jdc.jefferson.edu/tjucompmedctrfp/2

PubMed ID

24212931