The Conception of GCC- Specific Chimeric Antigen Receptors

Authors

Raven Smith-Parris, Cheyney UniversityFollow

Document Type

Article

Publication Date

8-8-2013

Comments

Paper is attached at bottom of page.

Abstract

Colorectal Cancer is an aggressive disease that claims the lives of both men and women every year. It is the second leading cause of cancer-related death in the U.S. The overwhelming mortality rate it amasses begs for the discovery of alternative forms of treatment. The nature of cancer requires immunotherapeutic approach that is tumor specific in nature. Adoptive T-cell therapy is an alternative that satisfies these conditions. Guanylyl Cyclase C is a receptor found on the luminal side of the gut that is tissue-specific for the intestinal epithelium. Further, its expression is maintained throughout colorectal tumorigenesis making in an excellent marker of metastatic disease. By employing the use of chimeric antigen receptors we have created twelve different CAR’s containing GCC-specificity which we will use to target tumors expressing Guanyl Cyclase C. We hypothesize that these new CAR’s will recognize GCC and induce T cell effector responses.

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