Document Type
Article
Publication Date
9-18-2024
Abstract
INTRODUCTION: Temporal lobe epilepsy (TLE), a debilitating neurological disorder, necessitates refined diagnostic and treatment strategies. This comprehensive review appraises the potential of positron emission tomography (PET) in enhancing the presurgical planning of Anterior Temporal Lobectomy (ATL) for patients afflicted with TLE.
METHODS: A comprehensive literature search was conducted using the PubMed, SCOPUS, and ScienceDirect databases from 1985 to 2022, following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for studies investigating PET and ATL. This review studied a range of radiotracers, including FDG, H
RESULTS: A total of 52 studies were included in the final analysis. Our analysis revealed that FDG-PET imaging was instrumental in identifying seizure foci and predicting postoperative results. It exhibited significant value in situations where structural abnormalities were absent on MRI scans. Furthermore, newer radiotracers such as 5-HT
CONCLUSION: PET imaging, although challenged by issues such as radiation exposure, limited accessibility, and high costs, offers considerable promise. Integration with other imaging modalities, such as EEG and MRI, has contributed to improved localization of epileptogenic foci and subsequently, enhanced surgical outcomes. Further research must focus on establishing the relative efficacy and optimal combinations of these radiotracers in the orchestration of ATL surgical planning and prognostication of postoperative outcomes for TLE patients. Encouragingly, these advancements hold the potential to revolutionize the management of TLE, delivering a better quality of life for patients.
Recommended Citation
Teichner, Eric M.; Subtirelu, Robert C; Patil, Shiv; Parikh, Chitra; Ashok, Arjun; Talasila, Sahithi; Anderson, Victoria; Khan, Talha; Su, Yvonne; Werner, Thomas; Alavi, Abass; and Revheim, Mona-Elisabeth, "Positron Emission Tomography (PET) in Presurgical Planning of Anterior Temporal Lobectomy: A Systematic Review of Efficacy and Limitations" (2024). SKMC Student Presentations and Publications. Paper 23.
https://jdc.jefferson.edu/skmcstudentworks/23
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Language
English
Comments
This article is the author's final published version in Clinical Neurology and Neurosurgery, Volume 246, November 2024, Article number 108562.
The published version is available at https://doi.org/10.1016/j.clineuro.2024.108562.
Copyright © 2024 The Author(s).