Document Type
Abstract
Publication Date
2-2021
Academic Year
2020-2021
Abstract
In pancreatic adenocarcinoma, it is believed that patients with proximal tumors (head) have earlier diagnosis and higher survival due to anatomic location compared to patients with distal tumors (body/tail). We hypothesized that differences in tumor biology would contribute to poorer survival in body/tail tumors compared to head tumors when diagnosed at the same stage.
We performed a retrospective chart review on 324 patients with pancreatic adenocarcinoma (236 head and 88 body/tail) diagnosed from 2011-2017. We gathered electronic health records from a single center with a high volume of pancreatic cancer directed surgery. We compared median patient survival from onset of diagnosis based on cancer staging and tumor location.
The overall body/tail cancer survival was significantly less than pancreatic head cancer (11.2 months body/tail compared to 16 months head, p=0.015). When broken down individually by stage at diagnosis or surgery, the survival for body/tail cases was not statistically significant to pancreatic head cases (p>0.05). After adjusting for both stage and surgery, the hazard ratio of body/tail reduced from 1.42 to 0.96.
The overall survival of pancreatic head cancer was significantly higher than that of the body/tail cancer, which was attributed to the head group being diagnosed earlier and/or underwent surgery. The head group’s survival advantage diminishes when corrected by stage and surgery and has a similar survival to the body/tail cancer. This result less likely supports a difference in tumor biology on survival.
Recommended Citation
Lam, Sophia; Zukas, Randi; Micaily, Ida; and Mallick, Atrayee Basu, "Anatomic location and mortality of pancreatic adenocarcinoma: A single institution study" (2021). Phase 1. Paper 12.
https://jdc.jefferson.edu/si_ctr_2023_phase1/12
Language
English
