Document Type
Article
Publication Date
9-1-2024
Abstract
BACKGROUND: Autologous chondrocyte implantation (ACI) and matrix-induced autologous chondrocyte implantation (MACI) are 2-stage procedures requiring an index full-thickness cartilage biopsy. Only a portion of patients ultimately undergo second-stage ACI/MACI.
PURPOSE: To identify patients with articular cartilage defects who underwent arthroscopic debridement with biopsy for ACI/MACI and compare those who did with those who did not proceed with implantation within 2 years after biopsy. Additionally, the authors sought to identify why patients did not proceed with implantation.
STUDY DESIGN: Case-control study; Level of evidence, 3.
METHODS: Patients who underwent arthroscopy and autologous chondrocyte biopsy from January 1, 2015, to December 31, 2019, and who had minimum 2-year follow-up data were grouped into those who proceeded with second-stage ACI/MACI (implant group; n = 97) and those who did not (biopsy group; n = 63). Demographic factors, cartilage defect characteristics, and preoperative International Knee Documentation Committee (IKDC) scores were analyzed. Patients in both groups were evaluated postoperatively using the IKDC, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Single Assessment Numeric Evaluation (SANE), and visual analog scale (VAS) for pain, and patients who did not undergo implantation were asked for their reasoning.
RESULTS: Body mass index (BMI) (
CONCLUSION: Patients who proceeded to the second stage of chondrocyte implantation via either ACI or MACI had higher-grade articular defects and higher BMI compared with those who underwent biopsy with concomitant debridement chondroplasty alone. Postoperative outcomes were similar between the groups.
Recommended Citation
Kemler, Bryson R.; Johnson, Emma E.; Evert, Brad M.; Dees, Azra N.; Giakas, Alec M.; Hanna, Adeeb Jacob; D'Amore, Taylor; Freedman, Kevin B.; and Hammoud, Sommer, "Analysis of Patients Who Undergo Index Arthroscopy With Biopsy but Not Implantation for Staged Chondrocyte Cell Transplantation" (2024). Rothman Institute Faculty Papers. Paper 271.
https://jdc.jefferson.edu/rothman_institute/271
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Language
English
Comments
This article is the author's final published version in Orthopaedic Journal of Sports Medicine, Volume 12, Issue 9, September 2024.
The published version is available at https://doi.org/10.1177/23259671241271705.
Copyright © 2024 The Author(s).