Document Type
Article
Publication Date
2022
Abstract
Previous in vitro and in vivo studies have indicated that tissue engineering scaffolds, including Schwann cells, may improve axonal regeneration, particularly in combination with Methylprednisolone as an influential neuroprotective factor. The primary aim of this study was to design composite electrospun scaffolds based on polylactic acid (PLA)/ hyaluronic acid (HA) containing various percentages (0.05–2% (w/v)) of Methylprednisolone (MP) with suitable mechanical and chemical properties for soft tissue especially to promote nerve growth. For the first time, MP was implicated in a PLA/HA nanofibrous and its effect on fiber’s properties was scrutinized as a candidate for nerve tissue.
Recommended Citation
Keikha, Mehdi; Entekhabi, Elahe; Shokrollahi, Mahvash; Nazarpak, Masoumeh Haghbin; Hassannejad, Zahra; Akbari, Somaye; Vaccaro, Alex R.; and Rahimi-Movaghar, Vafa, "Fabrication and Characterization of Methylprednisolone-Loaded Polylactic Acid/Hyaluronic Acid Nanofibrous Scaffold for Soft Tissue Engineering" (2022). Rothman Institute Faculty Papers. Paper 187.
https://jdc.jefferson.edu/rothman_institute/187
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Language
English
Comments
This article is the author's final published version in Journal of Industrial Textiles, Volume 52, July-December 2022.
The published version is available at https://doi.org/10.1177/15280837221116593. Copyright © The Author(s) 2022.