Early General Hypothermia Improves Motor Function after Spinal Cord Injury in Rats; a Systematic Review and Meta-Analysis.

Authors

Mahmoud Yousefifard, Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
Mohammad Hossein Vazirizadeh-Mahabadi, Student Research Committee, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
Leila Haghani, School of Medicine, International Campus, Tehran University of Medical Science, Tehran, Iran
Farhad Shokraneh, Cochrane Schizophrenia Group, Institute of Mental Health, University of Nottingham, Nottingham, United Kingdom
Alex R. Vaccaro, Department of Orthopedics and Neurosurgery, Rothman Institute, Thomas Jefferson University, Philadelphia, United StatesFollow
Vafa Rahimi-Movaghar, Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran; Brain and Spinal Injuries Research Center (BASIR), Neuroscience Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
Mostafa Hosseini, Pediatric Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Document Type

Article

Publication Date

10-6-2020

Comments

This article has been peer reviewed. It was published in: Archives of Academic Emergency Medicine.

Volume 8, Issue 1, October 2020, Pages 2-12.

The published version is available at DOI: 10.22037/aaem.v8i1.739

Copyright © 2020, Archives of Academic Emergency Medicine. All Rights Reserved

Abstract

Introduction: There is still controversy about the effect of early hypothermia on the outcome of spinal cord injury (SCI). The aim of this review article is to investigate the effect of local or general hypothermia on improving the locomotion after traumatic SCI.

Methods: Electronic databases (Medline and Embase) were searched from inception until May 7, 2018. Two independent reviewers screened and summarized the relevant experimental studies on hypothermia efficacy in traumatic SCI. The data were analyzed and the findings were presented as pooled standardized mean difference (SMD) and 95% confidence interval (95% CI).

Results: 20 papers contain-ing 30 separate experiments were included in meta-analysis. The onset of hypothermia varied between 0 and 240minutes after SCI. Administration of hypothermia has a positive effect on locomotion following SCI (SMD=0.5695% CI: 0.18-0.95, p=0.004). Subgroup analysis showed that general hypothermia improves locomotion recov-ery (SMD =0.89, 95% CI: 0.42 to 1.36; p <0.0001), while local hypothermia does not have a significant effect onmotor recovery (SMD=0.20, 95 % CI: -0.36-0.76, p=0.478). In addition, general hypothermia was found to affectmotor recovery only if its duration was between 2 and 8 hours (SMD=0.89; p<0.0001) and the target temperaturefor induction of hypothermia was between 32 and 35◦C C (SMD=0.83; p<0.0001).

Conclusion: We found that general hypothermia improves locomotion after SCI in rats. Duration of induction and the target temperature are two essential considerations for general therapeutic hypothermia.

Recommended Citation

Yousefifard, Mahmoud; Vazirizadeh-Mahabadi, Mohammad Hossein; Haghani, Leila; Shokraneh, Farhad; Vaccaro, Alex R.; Rahimi-Movaghar, Vafa; and Hosseini, Mostafa, "Early General Hypothermia Improves Motor Function after Spinal Cord Injury in Rats; a Systematic Review and Meta-Analysis." (2020). Rothman Institute Faculty Papers. Paper 131.
https://jdc.jefferson.edu/rothman_institute/131

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License

Language

English