Low Dose Aspirin: An Effective Chemoprophylaxis for Preventing Venous Thromboembolic Events

Authors

Javad Parvizi, MD, FRCS, Rothman Institute, Thomas Jefferson UniversityFollow
Antonia F. Chen, MD, MBA, Rothman Institute, Thomas Jefferson UniversityFollow
Camilo Restrepo, MD, Rothman Institute, Thomas Jefferson UniversityFollow
Ronald Huang, MD, Rothman Institute at Thomas Jefferson UniversityFollow
Jenny Cal, BS, Rothman Institute, Thomas Jefferson UniversityFollow
William J. Hozack, MD, Rothman Institute at Thomas Jefferson University HospitalFollow
Jess H. Lonner, MD, Rothman Institute, Thomas Jefferson University, Philadelphia, USAFollow

Document Type

Poster

Publication Date

3-26-2015

Comments

Poster presented at American Academy of Orthopaedic Surgeons in Las Vegas Nevada.

Abstract

The available guidelines, endorsed by Surgical Care Improvement Project (SCIP), have advocated that aspirin (ASA) is a safe and eff­ective strategy for venous thromboembolic events (VTE) prophylaxis following total joint arthroplasty (TJA). The optimal dose of aspirin for this purpose is not known. The first guidelines for prevention of VTE that were issued by the American Academy of Orthopedic Surgeons recommended 325 mg Bis in die (twice a day) (bid) for this purpose with the recommendation having a 1C grade (little evidence to support the recommendation). It is known that platelet aggregation inhibition occurs at lower doses. Traditionally, ASA 81mg has been used as a cardioprotective medication. Additionally, all available randomized studies, including the sentinel study on Pulmonary Embolism Prevention (PEP) trial1-4 have used lower doses of ASA. It was our hypothesis that lower dose aspirin is likely to be as eff­ective as higher dose aspirin while reducing the gastrointestinal side e­ffects associated with the higher dose aspirin.

Recommended Citation

Parvizi, MD, FRCS, Javad; Chen, MD, MBA, Antonia F.; Restrepo, MD, Camilo; Huang, MD, Ronald; Cal, BS, Jenny; Hozack, MD, William J.; and Lonner, MD, Jess H., "Low Dose Aspirin: An Effective Chemoprophylaxis for Preventing Venous Thromboembolic Events" (2015). Rothman Institute Conference Posters. Paper 10.
https://jdc.jefferson.edu/rothinsposters/10