Beyond DNA repair: DNA-PK function in cancer.
Document Type
Article
Publication Date
10-1-2014
Abstract
UNLABELLED: The DNA-dependent protein kinase (DNA-PK) is a pivotal component of the DNA repair machinery that governs the response to DNA damage, serving to maintain genome integrity. However, the DNA-PK kinase component was initially isolated with transcriptional complexes, and recent findings have illuminated the impact of DNA-PK-mediated transcriptional regulation on tumor progression and therapeutic response. DNA-PK expression has also been correlated with poor outcome in selected tumor types, further underscoring the importance of understanding its role in disease. Herein, the molecular and cellular consequences of DNA-PK are considered, with an eye toward discerning the rationale for therapeutic targeting of DNA-PK.
SIGNIFICANCE: Although DNA-PK is classically considered a component of damage response, recent findings illuminate damage-independent functions of DNA-PK that affect multiple tumor-associated pathways and provide a rationale for the development of novel therapeutic strategies.
Recommended Citation
Goodwin, Jonathan F and Knudsen, Karen E, "Beyond DNA repair: DNA-PK function in cancer." (2014). Department of Radiation Oncology Faculty Papers. Paper 57.
https://jdc.jefferson.edu/radoncfp/57
PubMed ID
25168287
Comments
This article has been peer reviewed. It was published in: Cancer Discovery.
Volume 4, Issue 10, 1 October 2014, Pages 1126-1139.
The published version is available at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184981/
Copyright © 2014 American Association for Cancer Research.