Document Type
Article
Publication Date
12-27-2021
Abstract
Mild traumatic brain injury (mTBI) accounts for more than 80% of people experiencing brain injuries. Symptoms of mTBI include short-term and long-term adverse clinical outcomes. In this study, resting-state functional magnetic resonance imaging (rs-fMRI) was conducted to measure voxel-based indices including fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), and functional connectivity (FC) in patients suffering from chronic mTBI; 64 patients with chronic mTBI at least 3 months post injury and 40 healthy controls underwent rs-fMRI scanning. Partial correlation analysis controlling for age and gender was performed within mTBI cohort to explore the association between rs-fMRI metrics and neuropsychological scores. Compared with controls, chronic mTBI patients showed increased fALFF in the left middle occipital cortex (MOC), right middle temporal cortex (MTC), and right angular gyrus (AG), and increased ReHo in the left MOC and left posterior cingulate cortex (PCC). Enhanced FC was observed from left MOC to right precuneus; from right MTC to right superior temporal cortex (STC), right supramarginal, and left inferior parietal cortex (IPC); and from the seed located at right AG to left precuneus, left superior medial frontal cortex (SMFC), left MTC, left superior temporal cortex (STC), and left MOC. Furthermore, the correlation analysis revealed a significant correlation between neuropsychological scores and fALFF, ReHo, and seed-based FC measured from the regions with significant group differences. Our results demonstrated that alterations of low-frequency oscillations in chronic mTBI could be representative of disruption in emotional circuits, cognitive performance, and recovery in this cohort.
Recommended Citation
Vedaei, Faezeh; Newberg, MD, Andrew B.; Alizadeh, Mahdi; Muller, Jennifer; Shahrampour, Shiva; Middleton, MS, Devon; Zabrecky, George; Wintering, Nancy; Bazzan, Anthony J. MD; Monti, MD, Daniel A.; and Mohamed, PhD, Feroze, "Resting-State Functional MRI Metrics in Patients With Chronic Mild Traumatic Brain Injury and Their Association With Clinical Cognitive Performance." (2021). Department of Radiology Faculty Papers. Paper 119.
https://jdc.jefferson.edu/radiologyfp/119
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
35027887
Language
English
Comments
This article is the author's final published version in Frontiers in Human Neuroscience, Volume 15, December 2021, Article number 768485.
The published version is available at https://doi.org/10.3389/fnhum.2021.768485.
Copyright © 2021 Vedaei, Newberg, Alizadeh, Muller, Shahrampour, Middleton, Zabrecky, Wintering, Bazzan, Monti and Mohamed.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
This study was supported by a gift from the Marcus Foundation. The financial support from the Radiology Department of Thomas Jefferson University Hospital is greatly appreciated.