Bronchoalveolar Lavage Neutrophils and Matrix Metalloproteinase-9 in Sarcoidosis Clinical Phenotypes: Implications for Tissue Remodeling Leading to Pulmonary Fibrosis

Authors

Rafael L. Perez, MD, Thomas Jefferson UniversityFollow
Jeff Ritzenthaler, Thomas Jefferson UniversityFollow
E. Torres-Gonzalez, Thomas Jefferson University
Prarthna Chandar, MD, Thomas Jefferson UniversityFollow
Daniel Kramer, MD, Thomas Jefferson UniversityFollow
Jesse Roman, MD, Thomas Jefferson UniversityFollow

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Description

Introduction

Pulmonary sarcoidosis may resolve or progress to advanced stages. Increased lung neutrophils obtained by bronchoalveolar lavage are found in advanced pulmonary sarcoidosis. Persistence of a neutrophilic alveolitis has been postulated to result in tissue injury and remodeling that leads to fibrosis and clinical features of advanced disease. Since neutrophils are a source of matrix-degrading proteins like matrix metalloproteinases (MMPs), we hypothesized that PMNs promote disease progression through the release of MMPs. This work explores the relationship between lung neutrophils and MMP9 levels and activity and how they are associated with sarcoidosis clinical phenotypes.

Publication Date

7-15-2024

Keywords

sarcoidosis, neutrophils, matrix metalloproteinases

Disciplines

Medical Specialties | Medicine and Health Sciences | Pulmonology

Comments

Presented at the 2024 Americas Association of Sarcoidosis and Other Granulomatous Disorders (AASOG) Conference.

Recommended Citation

Perez, MD, Rafael L.; Ritzenthaler, Jeff; Torres-Gonzalez, E.; Chandar, MD, Prarthna; Kramer, MD, Daniel; and Roman, MD, Jesse, "Bronchoalveolar Lavage Neutrophils and Matrix Metalloproteinase-9 in Sarcoidosis Clinical Phenotypes: Implications for Tissue Remodeling Leading to Pulmonary Fibrosis" (2024). Division of Pulmonary and Critical Care Medicine Posters. 6.
https://jdc.jefferson.edu/pulmcritcareposters/6