- Identify OGR1 as the principal proton-sensing receptor in the airway, capable of regulating airway resistance via its function of airway smooth muscle.
- Identify inflammation, and microaspiration of acid, as two mediators of low pH in the airway lumen.
- List 2 specific drugs that can function as OGR1 activators and potential asthma therapeutics.
Presentation: PowerPoint slides only, no audio
Recommended CitationPenn, PhD, Raymond B., "Proton-sensing receptors- therapeutic targets in the management of asthma?" (2014). Division of Pulmonary and Critical Care Medicine Presentations and Grand Rounds. Presentation 111.