Document Type
Presentation
Publication Date
10-8-2014
Abstract
Objectives:
- Identify OGR1 as the principal proton-sensing receptor in the airway, capable of regulating airway resistance via its function of airway smooth muscle.
- Identify inflammation, and microaspiration of acid, as two mediators of low pH in the airway lumen.
- List 2 specific drugs that can function as OGR1 activators and potential asthma therapeutics.
Presentation: PowerPoint slides only, no audio
Recommended Citation
Penn, PhD, Raymond B., "Proton-sensing receptors- therapeutic targets in the management of asthma?" (2014). Division of Pulmonary and Critical Care Medicine Presentations and Grand Rounds. Presentation 111.
https://jdc.jefferson.edu/pulmcritcaregrandrounds/111
Comments
The major focus of my research is to identify cellular and molecular mechanisms by which G protein-coupled receptors (GPCRs) mediate important functions in airway cells. GPCR signaling regulates contractile function, synthesis and release of autocrine factors, and cell growth/survival in various airway cells, including airway smooth muscle (ASM), airway epithelium, lung fibroblasts, and T lymphocytes. Aberrant GPCR signaling or exaggerated presentation of GPCR stimuli can promote ASM hypercontractility, airway remodeling, and ASM hyperplasia/hypertrophy, all of which contribute to the pathogenesis of asthma and COPD. Moreover, GPCRs appear to mediate important mitogenic and survival signaling pathways in cells comprising the tumor microenvironment- including epithelia, fibroblasts, stem cells, and inflammatory cells- rendering them potentially important therapeutic targets in the treatment of cancer. Finally, many GPCR genes possess mutations that alter their expression or function; we are particularly interested in characterizing such altered function and its contribution to disease state or disease therapy.