Document Type
Article
Publication Date
11-1-2024
Abstract
The translation of pre-clinical anti-cancer therapies to regulatory approval has been promising, but slower than hoped. While innovative and effective treatments continue to achieve or seek approval, setbacks are often attributed to a lack of efficacy, failure to achieve clinical endpoints, and dose-limiting toxicities. Successful efforts have been characterized by the development of therapeutics designed to specifically deliver optimal and effective dosing to tumour cells while minimizing off-target toxicity. Much effort has been devoted to the rational design and application of synthetic nanoparticles to serve as targeted therapeutic delivery vehicles. Several challenges to the successful application of this modality as delivery vehicles include the induction of a protracted immune response that results in their rapid systemic clearance, manufacturing cost, lack of stability, and their biocompatibility. Extracellular vesicles (EVs) are a heterogeneous class of endogenous biologically produced lipid bilayer nanoparticles that mediate intercellular communication by carrying bioactive macromolecules capable of modifying cellular phenotypes to local and distant cells. By genetic, chemical, or metabolic methods, extracellular vesicles (EVs) can be engineered to display targeting moieties on their surface while transporting specific cargo to modulate pathological processes following uptake by target cell populations. This review will survey the types of EVs, their composition and cargoes, strategies employed to increase their targeting, uptake, and cargo release, and their potential as targeted anti-cancer therapeutic delivery vehicles.
Recommended Citation
Jackson Cullison, Stephanie R.; Flemming, Joseph P.; Karagoz, Kubra; Wermuth, Peter J.; and Mahoney, Mỹ G., "Mechanisms of Extracellular Vesicle Uptake and Implications for the Design of Cancer Therapeutics" (2024). Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers. Paper 50.
https://jdc.jefferson.edu/ppcbfp/50
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
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Language
English
Comments
This article is the author's final published version in Journal of Extracellular Biology, Volume 3, Issue 11, November 2024, Article number e70017.
The published version is available at https://doi.org/10.1002/JEX2.70017.Copyright © 2024 The Author(s).
See Correction in Additional Files section below.