Document Type
Article
Publication Date
11-14-2025
Abstract
Bifidobacterium has captured major attention recently because of its health benefits and extensive research highlighting its potential in cancer treatment and prevention. Evidence suggests that bifidobacterium can actively fight against various types of cancer, including those of the colon, lungs, breast, and stomach. Research indicates that several species of bifidobacterium can potentiate the action of chemotherapy, immunotherapy and radiation therapy in battling tumors, and reducing their adverse effects. Bifidobacteria shows its multipronged effect by modulating various immunomodulatory and inflammatory signaling pathways, potentially leading to the suppression of tumor growth. Moreover, different species of bifidobacteria are known to regulate signaling molecules involved in promoting apoptosis. In addition, bifidobacteria have an impact on the regulation of diverse microRNAs. The anticancer properties of bifidobacterium may also stem from its ability to detoxify carcinogens and transform dietary elements. This review also covers how dietary factors can influence the prevalence of bifidobacterium in the gut, further affecting its anticancer capabilities.
Recommended Citation
Do, Hoang; Asiamah, Esther; Olorife, Mayanijesu; Pillai, Arathi; Patel, Sakshi; Selvakumar, Ponniah; Ray, Sidhartha D; and Lakshmikuttyamma, Ashakumary, "Mechanism of Anticancer Action of Bifidobacterium: Insights from Gut Microbiota" (2025). College of Pharmacy Faculty Papers. Paper 64.
https://jdc.jefferson.edu/pharmacyfp/64
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
41237260
Language
English
Comments
This article is the author's final published version in Oncotarget, Volume 16, 2025, Pages 818-833.
The published version is available at https://doi.org/10.18632/oncotarget.28779. Copyright © 2025 Do et al.