Inpatient Thrombophilia Workup After Acute VTE: The Tests That Don’t Pay it Forward

Start Date

5-15-2025 9:30 AM

End Date

5-15-2025 11:30 AM

Description

Background

  • Venous thromboembolism is a complex multifactorial disease that is influenced by genetic, environmental and behavioral risk factors.
  • Testing for inherited thrombophilia is commonly performed after a VTE event to help identify underlying genetic risk factors and assess the risk of recurrence.
  • Despite clinical guidelines advising against thrombophilia testing in patients with acute VTE, these tests continue to be ordered even though lab results are unlikely to alter treatment decisions

Problem Statement

  • At TJUH, activity and genetic assays are frequently ordered for patients with acute VTE during admission, increasing the likelihood of false- positive results that may lead to unnecessary follow-up testing, and added healthcare costs.

Keywords

venous thromboembolism, inherited thrombophilia

Comments

Presented at the 2025 Jefferson Health Equity and Quality Improvement (HEQI) Summit.

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May 15th, 9:30 AM May 15th, 11:30 AM

Inpatient Thrombophilia Workup After Acute VTE: The Tests That Don’t Pay it Forward

Background

  • Venous thromboembolism is a complex multifactorial disease that is influenced by genetic, environmental and behavioral risk factors.
  • Testing for inherited thrombophilia is commonly performed after a VTE event to help identify underlying genetic risk factors and assess the risk of recurrence.
  • Despite clinical guidelines advising against thrombophilia testing in patients with acute VTE, these tests continue to be ordered even though lab results are unlikely to alter treatment decisions

Problem Statement

  • At TJUH, activity and genetic assays are frequently ordered for patients with acute VTE during admission, increasing the likelihood of false- positive results that may lead to unnecessary follow-up testing, and added healthcare costs.