Document Type
Presentation
Publication Date
2-25-2016
Abstract
BACKGROUND
•Microcystic, Elongated and Fragmented (MELF) is a well-recognized pattern of uterine endometrioid carcinoma (UEC) associated with lymphovascular space invasion and occult lymph node metastasis
•MELF in UEC may be seen with Lynch Syndrome
•MELF in UEC is hypothesized to be histologic evidence of an epithelial mesenchymal transition
•MELF pattern invasion in ovarian endometrioid carcinoma (OEC) was first described at USCAP 2015 •
Current study evaluates MELF in OEC for
•Prognostic implications
•Immunohistochemical (IHC) profile related to
•Lynch Syndrome
•Epithelial mesenchymal transition
DESIGN
•42 consecutive cases of OEC without concurrent UEC (1996-2014) evaluated by 2 pathologists
•MELF defined as at least three glands fulfilling histologic criteria
•32 cases had blocks available for staining
•MLH1, PMS2, MSH2 and MSH6 for mismatch repair (MMR) protein expression
•Graded as “retained” or “lost”
•β-catenin, e-cadherin, CK19 and cyclin D1 for evidence of epithelial mesenchymal transition
•Graded as “rare” (75% cells stain)
•Retrospective chart review of clinical and demographic features and overall survival
•Data analyzed using Fisher exact test analysis
•Survival analyzed using Kaplan-Meier method
Recommended Citation
Goldberg, MD, Allison F.; Cooper, MD, Lauren; Cotiis, D. De; Rosenblum, MD, PhD, Norman G.; and Chan, MD, Joanna, "Microcystic, Elongated, and Fragmented (MELF) Pattern Invasion in Ovarian Endometrioid Carcinoma: Immunohistochemical Profile and Prognostic Implications" (2016). Department of Pathology, Anatomy, and Cell Biology Resident's Posters. Paper 8.
https://jdc.jefferson.edu/pacbresidentposters/8
