Immunohistochemistry for the Proliferation Markers Ki67 and PHH3 in Cell Block Material of Basaloid Salivary Gland Neoplasms is Predictive of Malignancy

Authors

Robert Post, Thomas Jefferson UniversityFollow
Zach Breslin, Thomas Jefferson UniversityFollow
Yanki Yarman, Thomas Jefferson UniversityFollow
Stacey Gargano, Thomas Jefferson UniversityFollow

Files

Description

Background: Basaloid salivary gland neoplasms (BSGNs) are notoriously difficult to classify in fine needle aspiration (FNA) specimens due to the morphologic overlap shown by the various benign and malignant entities in this category1,2,3. Adenoid cystic carcinoma (AdCC) represents a particular diagnostic challenge, as it typically shows low grade cytologic features despite its aggressive clinical behavior and need for more extensive surgery4. We examined whether the proliferation markers Ki67 and PHH3 could help predict malignancy in BSGNs, thus improving diagnostic accuracy and optimizing patient care.

Publication Date

3-20-2023

Keywords

cytology, basaloid salivary neoplasms, Ki67, cell block

Disciplines

Medicine and Health Sciences | Pathology

Comments

Presented at the 2023 United States and Canadian Academy of Pathology Annual Meeting.

Recommended Citation

Post, Robert; Breslin, Zach; Yarman, Yanki; and Gargano, Stacey, "Immunohistochemistry for the Proliferation Markers Ki67 and PHH3 in Cell Block Material of Basaloid Salivary Gland Neoplasms is Predictive of Malignancy" (2023). Department of Pathology, Anatomy, and Cell Biology Posters. 20.
https://jdc.jefferson.edu/pacbposters/20