Document Type


Publication Date

March 2006


This article has been peer reviewed and published in Nature Reviews Molecular Computational Biology 7(3): 165-176, March 2006. The published article is available at Copyright © 2006 Nature Publishing Group.


The specificity of cellular responses to receptor stimulation is encoded by the spatial and temporal dynamics of downstream signalling networks. Computational models provide insights into the intricate relationships between stimuli and responses and reveal mechanisms that enable networks to amplify signals, reduce noise and generate discontinuous bistable dynamics or oscillations. These temporal dynamics are coupled to precipitous spatial gradients of signalling activities, which guide pivotal intracellular processes, but also necessitate mechanisms to facilitate signal propagation across a cell.