The specificity of cellular responses to receptor stimulation is encoded by the spatial and temporal dynamics of downstream signalling networks. Computational models provide insights into the intricate relationships between stimuli and responses and reveal mechanisms that enable networks to amplify signals, reduce noise and generate discontinuous bistable dynamics or oscillations. These temporal dynamics are coupled to precipitous spatial gradients of signalling activities, which guide pivotal intracellular processes, but also necessitate mechanisms to facilitate signal propagation across a cell.
Recommended CitationKholodenko, Boris N. PhD, DSci, "Cell-signalling dynamics in time and space" (2006). Department of Pathology, Anatomy, and Cell Biology Faculty Papers. Paper 5.