Document Type
Article
Publication Date
5-11-2020
Abstract
Genes that establish the circadian clock have differential expression with respect to solar time in central and peripheral tissues. Here, we find circadian-time-induced differential expression in a large number of genes not associated with circadian rhythms in two brain regions lacking overt circadian function: the dorsal vagal complex (DVC) and the central nucleus of the amygdala (CeA). These regions primarily engage in autonomic, homeostatic, and emotional regulation. However, we find striking diurnal shifts in gene expression in these regions of male Sprague Dawley rats with no obvious patterns that could be attributed to function or region. These findings have implications for the design of gene expression studies as well as for the potential effects of xenobiotics on these regions that regulate autonomic and emotional states.
Recommended Citation
Staehle, Mary M; O'Sullivan, Sean; Vadigepalli, Rajanikanth; Kernan, Kate F; Gonye, Gregory E; Ogunnaike, Babatunde A; and Schwaber, James S., "Diurnal Patterns of Gene Expression in the Dorsal Vagal Complex and the Central Nucleus of the Amygdala - Non-rhythm-generating Brain Regions" (2020). Department of Pathology, Anatomy, and Cell Biology Faculty Papers. Paper 296.
https://jdc.jefferson.edu/pacbfp/296
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
32477043
Language
English
Comments
This article is the author’s final published version in Frontiers in Neuroscience, Volume 14, May 2020, Article number 375.
The published version is available at https://doi.org/10.3389/fnins.2020.00375. Copyright © Staehle et al.