Document Type
Article
Publication Date
3-20-2019
Abstract
Close proximities between organelles have been described for decades. However, only recently a specific field dealing with organelle communication at membrane contact sites has gained wide acceptance, attracting scientists from multiple areas of cell biology. The diversity of approaches warrants a unified vocabulary for the field. Such definitions would facilitate laying the foundations of this field, streamlining communication and resolving semantic controversies. This opinion, written by a panel of experts in the field, aims to provide this burgeoning area with guidelines for the experimental definition and analysis of contact sites. It also includes suggestions on how to operationally and tractably measure and analyze them with the hope of ultimately facilitating knowledge production and dissemination within and outside the field of contact-site research.
Recommended Citation
Scorrano, Luca; De Matteis, Maria Antonietta; Emr, Scott; Giordano, Francesca; Hajnóczky, György; Kornmann, Benoît; Lackner, Laura L.; Levine, Tim P.; Pellegrini, Luca; Reinisch, Karin; Rizzuto, Rosario; Simmen, Thomas; Stenmark, Harald; Ungermann, Christian; and Schuldiner, Maya, "Coming together to define membrane contact sites." (2019). Department of Pathology, Anatomy, and Cell Biology Faculty Papers. Paper 272.
https://jdc.jefferson.edu/pacbfp/272
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
30894536
Language
English
Comments
This article has been peer reviewed. It is the author’s final published version in Nature Communications, Volume 10, Issue 1, March 2019, Article number 1287.
The published version is available at https://doi.org/10.1038/s41467-019-09253-3. Copyright © Scorrano et al.