Association of metabolic syndrome and change in Unified Parkinson's Disease Rating Scale scores.

Authors

Maureen Leehey, University of Colorado School of Medicine
Sheng Luo, University of Texas Health Science Center at Houston; University of Rochester; Duke University
Saloni Sharma, University of RochesterFollow
Anne-Marie A. Wills, Massachusetts General Hospital and Harvard Medical SchoolFollow
Jacquelyn L. Bainbridge, University of Colorado School of MedicineFollow
Pei Shieen Wong, Singapore General Hospital, Beth Israel Deaconess Medical Center and Harvard Medical SchoolFollow
David K. Simon, Beth Israel Deaconess Medical Center and Harvard Medical SchoolFollow
Jay S Schneider, Thomas Jefferson UniversityFollow
Yunxi Zhang, University of Texas Health Science Center at Houston; University of Rochester; University of Texas Health Science Center
Adriana Pérez, University of Texas Health Science Center
Rohit Dhall, University of Arkansas for Medical Sciences
Chadwick W. Christine, University of California San Francisco; University of Miami
Carlos Singer, University of Miami
Franca Cambi, University of Pittsburgh
James T Boyd, University of Vermont

Document Type

Article

Publication Date

10-24-2017

Comments

This article has been peer reviewed. It is the author’s final published version in Neurology

Volume 89, Issue 17, October 2017, Pages 1789-1794.

The published version is available at DOI: 10.1212/WNL.0000000000004572. Copyright © Leehey et al.

Abstract

OBJECTIVE: To explore the association between metabolic syndrome and the Unified Parkinson's Disease Rating Scale (UPDRS) scores and, secondarily, the Symbol Digit Modalities Test (SDMT).

METHODS: This is a secondary analysis of data from 1,022 of 1,741 participants of the National Institute of Neurological Disorders and Stroke Exploratory Clinical Trials in Parkinson Disease Long-Term Study 1, a randomized, placebo-controlled trial of creatine. Participants were categorized as having or not having metabolic syndrome on the basis of modified criteria from the National Cholesterol Education Program Adult Treatment Panel III. Those who had the same metabolic syndrome status at consecutive annual visits were included. The change in UPDRS and SDMT scores from randomization to 3 years was compared in participants with and without metabolic syndrome.

RESULTS: Participants with metabolic syndrome (n = 396) compared to those without (n = 626) were older (mean [SD] 63.9 [8.1] vs 59.9 [9.4] years; p < 0.0001), were more likely to be male (75.3% vs 57.0%; p < 0.0001), and had a higher mean uric acid level (men 5.7 [1.3] vs 5.3 [1.1] mg/dL, women 4.9 [1.3] vs 3.9 [0.9] mg/dL, p < 0.0001). Participants with metabolic syndrome experienced an additional 0.6- (0.2) unit annual increase in total UPDRS (p = 0.02) and 0.5- (0.2) unit increase in motor UPDRS (p = 0.01) scores compared with participants without metabolic syndrome. There was no difference in the change in SDMT scores.

CONCLUSIONS: Persons with Parkinson disease meeting modified criteria for metabolic syndrome experienced a greater increase in total UPDRS scores over time, mainly as a result of increases in motor scores, compared to those who did not. Further studies are needed to confirm this finding.

CLINICALTRIALSGOV IDENTIFIER: NCT00449865.

Recommended Citation

Leehey, Maureen; Luo, Sheng; Sharma, Saloni; Wills, Anne-Marie A.; Bainbridge, Jacquelyn L.; Wong, Pei Shieen; Simon, David K.; Schneider, Jay S; Zhang, Yunxi; Pérez, Adriana; Dhall, Rohit; Christine, Chadwick W.; Singer, Carlos; Cambi, Franca; and Boyd, James T, "Association of metabolic syndrome and change in Unified Parkinson's Disease Rating Scale scores." (2017). Department of Pathology, Anatomy, and Cell Biology Faculty Papers. Paper 224.
https://jdc.jefferson.edu/pacbfp/224

PubMed ID

28972194