Strategic distribution of the mitochondrial Ca2+ uniporter in cardiac mitochondria

Authors

• Sergio De La Fuente, Pathology, Anatomy & Cell Biol., Thomas Jefferson University, Philadelphia, PA, USAFollow
• Caitlin Vail, Pathology, Anatomy & Cell Biol., Thomas Jefferson University, Philadelphia, PA, USAFollow
• Elorm J. Agra, Pathology, Anatomy & Cell Biol., Thomas Jefferson University, Philadelphia, PA, USAFollow
• Kira Holmstrom, Center for Molecular Medicine, Lab. of Molecular Biology, NIH-NHLBI, Bethesda, MD, USAFollow
• Junhui Sun, Systems Biology Center, Laboratory of Cardiac Physiology, NIH-NHLBI, Bethesda, MD, USAFollow
• Jyotsna Mishra, Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, USAFollow
• Toren Finkel, Center for Molecular Medicine, Lab. of Molecular Biology, NIH-NHLBI, Bethesda, MD, USAFollow
• Elizabeth Murphy, Systems Biology Center, Laboratory of Cardiac Physiology, NIH-NHLBI, Bethesda, MD, USAFollow
• Shey-Shing Sheu, Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, USAFollow
• György Csordás, Pathology, Anatomy & Cell Biol., Thomas Jefferson University, Philadelphia, PA, USAFollow

Document Type

Presentation

Publication Date

6-16-2015

Comments

Presented at 10th Annual Postdoctoral Research Symposium.

Abstract

Background:

1) Control of the mitochondrial ATP production by SR-derived Ca²⁺ signals includes local, nanodomain Ca²⁺ transfer from ryanodine receptors (RyR2) to the mitochondrial matrix (excitation-bioenergetics coupling).

2) Ca²⁺ crosses the inner mitochondrial membrane (IMM) via the mtCU, a low-affinity Ca²⁺-activated Ca²⁺ channel complex.

3) The surface area of cardiac IMM is extensively enhanced by cristae folding; however, mitoplast patch clamp studies showed mtCU current density the lowest amongst a range of tissues (Fieni 2012. Nat Commun).

Recommended Citation

De La Fuente, Sergio; Vail, Caitlin; Agra, Elorm J.; Holmstrom, Kira; Sun, Junhui; Mishra, Jyotsna; Finkel, Toren; Murphy, Elizabeth; Sheu, Shey-Shing; and Csordás, György, "Strategic distribution of the mitochondrial Ca2+ uniporter in cardiac mitochondria" (2015). Department of Pathology, Anatomy, and Cell Biology Faculty Papers. Paper 167.
https://jdc.jefferson.edu/pacbfp/167