Thyroid Cancer Metabolism: A Review

Authors

Kurren Gill, BA, Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, PAFollow
Patrick Tassone, MD,, Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, PAFollow
James Hamilton, MD, Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, PAFollow
Nikolaus Hjelm, MD, Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, PAFollow
Adam J. Luginbuhl, MD, Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, PAFollow
David Cognetti, MD, Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, PAFollow
Madalina Tuluc, MD, Department of Pathology, Thomas Jefferson University, Philadelphia, PAFollow
Ubaldo E. Martinez-Outshoorn, MD, Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PAFollow
Jennifer Johnson, MD, Department of Medical Oncology, Thomas Jefferson University, PAFollow
Joseph Curry, MD, Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, PAFollow

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Description

Abstract

Metabolic dysregulation within the tumor microenvironment (TME) is critical to the process of tumorigenesis in various cancer types. Thyrocyte metabolism in papillary and anaplastic thyroid cancer, however, remains poorly characterized, and studies analyzing the role of multicompartment metabolism in thyrocyte oncogenesis are sparse. We present a review of the current knowledge on cellular metabolism in non-cancerous and cancerous thyroid tissues, focusing on the monocarboxylate transporters MCT1 and MCT4, and on a transporter of the outer mitochondrial membrane TOMM20. Understanding the metabolic phenotype of tumor cells and associated stromal cells in thyroid cancer can have profound implications on the use of biomarker staining in detecting subclinical cancer, imaging as it relates to expression of various transport proteins, and therapeutic interventions that manipulate this dysregulated tumor metabolism to halt tumorigenesis and eradicate the cancer. Future studies are required to confirm the prognostic significance of these biomarkers and their correlation with existing staging schemas such as the AGES, AMES, ATA and MACIS scoring systems.

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Publication Date

3-1-2016

Keywords

Thyroid Cancer Metabolism, A Review, Department of Otolaryngology-Head and Neck Surgery; Department of Pathology, Anatomy, and Cell Biology; Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA

Disciplines

Oncology | Otolaryngology

Comments

Poster presented at: 2016 International Conference on Thyroid Disorders and Treatments in Philadelphia PA.

Recommended Citation

Gill, BA, Kurren; Tassone, MD,, Patrick; Hamilton, MD, James; Hjelm, MD, Nikolaus; Luginbuhl, MD, Adam J.; Cognetti, MD, David; Tuluc, MD, Madalina; Martinez-Outshoorn, MD, Ubaldo E.; Johnson, MD, Jennifer; and Curry, MD, Joseph, "Thyroid Cancer Metabolism: A Review" (2016). Department of Otolaryngology - Head and Neck Surgery Posters. 2.
https://jdc.jefferson.edu/otoposters/2