Document Type
Poster
Publication Date
6-14-2013
Abstract
Objective: To evaluate the potential for injectable, permanent bone augmentation by assessing the biocompatibility and bioactivity of subperiosteal hydroxylapatite (Radiesse) deposition in a rat model.
Methods: Fourteen adult Sprague Dawley rats were injected in the parietal skull with hydroxylapatite (n=10) or a carrier gel control (n=4), using a subperiosteal injection technique on the right and a subcutaneous injection technique on the left. At 1, 3, and 6 months, 3 rats (1 negative control, 2 variables) were sacrificed. At 12 months, the remaining 5 rats were sacrificed. After each harvest, the calvaria were examined under both light and polarized microscopy.
Results: The inflammatory response was limited in all specimens. Injectables were still present 12 months after the injection. New bone formation was only seen when the injection was located deep to a disrupted periosteum The odd of new bone formation was 48.949 times higher (95% CI (2.637, 3759.961), p = 0.002) with subperiosteal hydroxylapatite injections compared to all other combinations of injection plane and injectable.
Conclusion: This preliminary report of subperiosteal hydroxylapatite (Radiesse) injection in a rat model has verified the biocompatibility of injectable hydroxylapatite at the bony interface and suggests the potential for new bone formation.
Recommended Citation
Parkes, MD, William J.; Greywoode, MD, Jewel; O'Hara, MD, Brian J.; Heffelfinger, MD, Ryan N.; and Krein, MD, PhD, Howard, "A Preliminary Report of Percutaneous Craniofacial Osteoplasty in a Rat Calvarium" (2013). Department of Otolaryngology - Head and Neck Surgery Presentations and Grand Rounds. Presentation 16.
https://jdc.jefferson.edu/otograndrounds/16
Included in
Medical Anatomy Commons, Medical Cell Biology Commons, Medical Pathology Commons, Otolaryngology Commons
Comments
Poster presented at Pennsylvania Academy of Otolargology Head and Neck Surgery conference, Bedford Springs Resort.