Document Type
Article
Publication Date
1-1-2016
Abstract
BACKGROUND: Neurocysticercosis (NCC) is an invasive parasitic infection of the central nervous system caused by the larval stage of the tapeworm Taenia solium. The clinical manifestations of NCC depend on the parasitic load and location of infection, as well as the developmental stage of the cysticerci and host immune response, with symptoms ranging from subclinical headaches to seizures, cerebrovascular events, and life-threatening hydrocephalus. Racemose NCC represents a particularly severe variant of extraparenchymal NCC characterized by the presence of multiple confluent cysts within the subarachnoid space and is associated with increased morbidity and mortality, as well as a decreased response to treatment. Albendazole is the preferred drug for the treatment of racemose NCC due to its superior cerebrospinal fluid penetration compared to praziquantel and the ability to be used concomitantly with steroids.
CASE DESCRIPTION: In this report, we describe a 39-year-old man recently emigrated from Mexico with racemose NCC and hydrocephalus successfully treated with prolonged albendazole treatment, high-dose dexamethasone, and ventriculoperitoneal shunt placement for the relief of obstructive hydrocephalus.
CONCLUSIONS: Treatment of racemose NCC represents a significant clinical challenge requiring multimodal intervention to minimize infectious- and treatment-related morbidity. We review the clinical, diagnostic, and therapeutic features relevant to the management of this aggressive form of NCC.
Recommended Citation
Krupa, Kristin; Krupa, BS, Kelly; Pisculli, Mary L; Athas, Deena M; and Farrell, MD, Christopher J, "Racemose neurocysticercosis." (2016). Department of Neurosurgery Faculty Papers. Paper 79.
https://jdc.jefferson.edu/neurosurgeryfp/79
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 License.
PubMed ID
26958418
Comments
This article has been peer reviewed. It was published in: Surgical Neurology International.
Volume 7, Issue 1, 1 January 2016, Article number 12.
The published version is available at DOI: 10.4103/2152-7806.175881
Copyright © 2016 Surgical Neurology International
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