Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies

Authors

• Vinata Vedam-Mai, University of Florida
• Karl Deisseroth, Stanford University
• James Giordano, Georgetown University Medical Center
• Gabriel Lazaro-Munoz, Baylor College of Medicine
• Winston Chiong, University of California
• Nanthia Suthana, University of California, Los Angeles
• Jean-Philippe Langevin, University of California, Los Angeles
• Jay Gill, University of California, Los Angeles
• Wayne Goodman, Baylor College of Medicine
• Nicole R Provenza, Brown University
• Casey H Halpern, Stanford University Medical Center
• Rajat S Shivacharan, Stanford University Medical Center
• Tricia N Cunningham, Stanford University Medical Center
• Sameer A Sheth, Baylor College of Medicine
• Nader Pouratian, University of California, Los Angeles
• Katherine W Scangos, University of California, San Francisco
• Helen S Mayberg, Icahn School of Medicine at Mount Sinai
• Andreas Horn, University Medicine Berlin
• Kara A Johnson, University of Utah
• Christopher R Butson, University of Utah
• Ro'ee Gilron, University of California, San Francisco
• Coralie de Hemptinne, University of Florida
• Robert Wilt, University of California, San Francisco
• Maria Yaroshinsky, University of California, San Francisco
• Simon Little, University of California, San Francisco
• Philip Starr, University of California, San Francisco
• Greg Worrell, Mayo Clinic
• Prasad Shirvalkar, University of California, San Francisco
• Edward Chang, University of California, San Francisco
• Jens Volkmann, Universitätsklinikum Würzburg
• Muthuraman Muthuraman, University Medical Center of the Johannes Gutenberg-University Mainz
• Sergiu Groppa, University Medical Center of the Johannes Gutenberg-University Mainz
• Andrea A Kühn, Universitätsmedizin Berlin
• Luming Li, Tsinghua University
• Matthew Johnson, University of Minnesota
• Kevin J Otto, University of Florida
• Robert Raike, Restorative Therapies Group Implantables
• Steve Goetz, Restorative Therapies Group Implantables
• Chengyuan Wu, Thomas Jefferson University HospitalFollow
• Peter Silburn, The University of Queensland
• Binith Cheeran, Abbott
• Yagna J Pathak, Abbott
• Mahsa Malekmohammadi, Boston Scientific Neuromodulation
• Aysegul Gunduz, University of Florida
• Joshua K Wong, University of Florida
• Stephanie Cernera, University of Florida
• Aparna Wagle Shukla, University of Florida
• Adolfo Ramirez-Zamora, University of Florida
• Wissam Deeb, University of Massachusetts
• Addie Patterson, University of Florida
• Kelly D Foote, University of Florida
• Michael S Okun, University of Florida

Document Type

Article

Publication Date

4-19-2021

Comments

This article is the author’s final published version in Frontiers in Human Neuroscience, Volume 15, April 2021, Article number 644593

The published version is available at https://doi.org/10.3389/fnhum.2021.644593. Copyright © Vedam-Mai et al.

Corrigendum: Wei Hu was not included as an author in the published article. In the original article, we neglected to include the funders NPF and Tyler’s Hope to Wei Hu. In the original article, there was an error. A donation was omitted. A correction has been made to the Conflict of Interest Statement, with the following sentence added: “Research devices for Dr. Goodman’s NIH funded study were donated by Medtronic.” The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Abstract

We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. The emphasis is on cutting edge research and collaboration aimed to advance the DBS field. The Eighth Annual DBS Think Tank was held virtually on September 1 and 2, 2020 (Zoom Video Communications) due to restrictions related to the COVID-19 pandemic. The meeting focused on advances in: (1) optogenetics as a tool for comprehending neurobiology of diseases and on optogenetically-inspired DBS, (2) cutting edge of emerging DBS technologies, (3) ethical issues affecting DBS research and access to care, (4) neuromodulatory approaches for depression, (5) advancing novel hardware, software and imaging methodologies, (6) use of neurophysiological signals in adaptive neurostimulation, and (7) use of more advanced technologies to improve DBS clinical outcomes. There were 178 attendees who participated in a DBS Think Tank survey, which revealed the expansion of DBS into several indications such as obesity, post-traumatic stress disorder, addiction and Alzheimer’s disease. This proceedings summarizes the advances discussed at the Eighth Annual DBS Think Tank.

Recommended Citation

Vedam-Mai, Vinata; Deisseroth, Karl; Giordano, James; Lazaro-Munoz, Gabriel; Chiong, Winston; Suthana, Nanthia; Langevin, Jean-Philippe; Gill, Jay; Goodman, Wayne; Provenza, Nicole R; Halpern, Casey H; Shivacharan, Rajat S; Cunningham, Tricia N; Sheth, Sameer A; Pouratian, Nader; Scangos, Katherine W; Mayberg, Helen S; Horn, Andreas; Johnson, Kara A; Butson, Christopher R; Gilron, Ro'ee; de Hemptinne, Coralie; Wilt, Robert; Yaroshinsky, Maria; Little, Simon; Starr, Philip; Worrell, Greg; Shirvalkar, Prasad; Chang, Edward; Volkmann, Jens; Muthuraman, Muthuraman; Groppa, Sergiu; Kühn, Andrea A; Li, Luming; Johnson, Matthew; Otto, Kevin J; Raike, Robert; Goetz, Steve; Wu, Chengyuan; Silburn, Peter; Cheeran, Binith; Pathak, Yagna J; Malekmohammadi, Mahsa; Gunduz, Aysegul; Wong, Joshua K; Cernera, Stephanie; Wagle Shukla, Aparna; Ramirez-Zamora, Adolfo; Deeb, Wissam; Patterson, Addie; Foote, Kelly D; and Okun, Michael S, "Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies" (2021). Department of Neurosurgery Faculty Papers. Paper 153.
https://jdc.jefferson.edu/neurosurgeryfp/153

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

33953663

Language

English