Document Type
Article
Publication Date
1-1-2023
Abstract
Background: Genetic diversity in human leukocyte antigen (HLA) alleles across populations is a significant risk factor for drug-induced severe cutaneous adverse reactions (SCARs), e.g., carbamazepine (CBZ)- and lamotrigine (LTG)-induced StevensJohnson syndrome (SJS), and toxic epidermal necrolysis (TEN). The present study aimed to investigate the frequency of different HLA alleles in Iranian patients with CBZ- and LTG-induced SJS/TEN.
Methods:A case-control study was conducted from 2011 to 2018 at various hospitals affiliated with Shiraz University of Medical Sciences (Shiraz, Iran). A total of 31 patients receiving anticonvulsant drugs (CZB or LTG) were recruited and divided into two groups. The drug-induced group (n=14) included hospitalized patients due to CBZ- or LTG-induced SJS/TEN. The drug-tolerant group (n=17) included individuals receiving CBZ or LTG for at least three months with no adverse effects. In addition, 46 healthy individuals (control group) were recruited. The frequency of HLA-A, -B, and -DRB1 alleles in patients with CZB- or LTG-induced SJS/TEN was investigated. HLA typing was performed using the allele-specific polymerase chain reaction method. The Chi square test and Fisher’s exact test were used to determine a potential association between SJS/TEN and HLA alleles. P
Results: CBZ- or LTG-induced SJS/TEN was not significantly associated with HLA alleles. However, HLA-DRB1*01 showed a significantly higher frequency in patients with CBZ-induced SJS/TEN than the CBZ-tolerant patients (30% vs. 9%, P=0.07). Conclusion: Overall, no significant association was found between CBZ- or LTG-induced SJS/TEN and HLA alleles. Further largescale studies are required to substantiate our findings.
Recommended Citation
Dastgheib, Ladan; Rostami, Farima; Gharesi-Fard, Behrouz; Asadi-Pooya, Ali Akbar; Namjoo, Saba; Tahmasebi, Foroozan; and Hadibarhaghtalab, Maryam, "Association of Human Leukocyte Antigen Alleles with Carbamazepine-or Lamotrigine-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in an Iranian Population: A Case-control Study" (2023). Department of Neurology Faculty Papers. Paper 310.
https://jdc.jefferson.edu/neurologyfp/310
Creative Commons License
This work is licensed under a Creative Commons Attribution-No Derivative Works 4.0 License.
Language
English
Comments
This article is the author's final published version in Iranian Journal of Medical Sciences, Volume 48, Issue 1, January 2023, Pg. 70 - 76.
The published version is available at https://doi.org/10.30476/ijms.2022.91192.2241. Copyright © Iranian Journal of Medical Sciences.