Contribution of left supramarginal and angular gyri to episodic memory encoding: An intracranial EEG study.

Authors

Daniel Y. Rubinstein, Thomas Jefferson UniversityFollow
Liliana Camarillo-Rodriguez, Thomas Jefferson UniversityFollow
Mijail D. Serruya, Thomas Jefferson UniversityFollow
Nora A. Herweg, University of Pennsylvania
Zachary J. Waldman, Thomas Jefferson UniversityFollow
Paul A. Wanda, University of Pennsylvania
Ashwini D. Sharan, Thomas Jefferson UniversityFollow
Shennan A. Weiss, State University of New York Downstate Medical Center; New York City Health + Hospitals
Michael R. Sperling, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

11-1-2020

Comments

This article is the author’s final published version in NeuroImage, Volume 225, January 2021, Article number 117514.

The published version is available at https://doi.org/10.1016/j.neuroimage.2020.117514. Copyright © Rubinstein et al.

Publication made possible in part by support from the Jefferson Open Access Fund

Abstract

The role of the left ventral lateral parietal cortex (VPC) in episodic memory is hypothesized to include bottom-up attentional orienting to recalled items, according to the dual-attention model (Cabeza et al., 2008). However, its role in memory encoding could be further clarified, with studies showing both positive and negative subsequent memory effects (SMEs). Furthermore, few studies have compared the relative contributions of sub-regions in this functionally heterogeneous area, specifically the anterior VPC (supramarginal gyrus/BA40) and the posterior VPC (angular gyrus/BA39), on a within-subject basis. To elucidate the role of the VPC in episodic encoding, we compared SMEs in the intracranial EEG across multiple frequency bands in the supramarginal gyrus (SmG) and angular gyrus (AnG), as twenty-four epilepsy patients with indwelling electrodes performed a free recall task. We found a significant SME of decreased theta power and increased high gamma power in the VPC overall, and specifically in the SmG. Furthermore, SmG exhibited significantly greater spectral tilt SME from 0.5 to 1.6 s post-stimulus, in which power spectra slope differences between recalled and unrecalled words were greater than in the AnG (p = 0.04). These results affirm the contribution of VPC to episodic memory encoding, and suggest an anterior-posterior dissociation within VPC with respect to its electrophysiological underpinnings.

Recommended Citation

Rubinstein, Daniel Y.; Camarillo-Rodriguez, Liliana; Serruya, Mijail D.; Herweg, Nora A.; Waldman, Zachary J.; Wanda, Paul A.; Sharan, Ashwini D.; Weiss, Shennan A.; and Sperling, Michael R., "Contribution of left supramarginal and angular gyri to episodic memory encoding: An intracranial EEG study." (2020). Department of Neurology Faculty Papers. Paper 227.
https://jdc.jefferson.edu/neurologyfp/227

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

PubMed ID

33137477

Language

English