Document Type
Article
Publication Date
2-6-2018
Abstract
Memory failures are frustrating and often the result of ineffective encoding. One approach to improving memory outcomes is through direct modulation of brain activity with electrical stimulation. Previous efforts, however, have reported inconsistent effects when using open-loop stimulation and often target the hippocampus and medial temporal lobes. Here we use a closed-loop system to monitor and decode neural activity from direct brain recordings in humans. We apply targeted stimulation to lateral temporal cortex and report that this stimulation rescues periods of poor memory encoding. This system also improves later recall, revealing that the lateral temporal cortex is a reliable target for memory enhancement. Taken together, our results suggest that such systems may provide a therapeutic approach for treating memory dysfunction.
Recommended Citation
Ezzyat, Youssef; Wanda, Paul A.; Levy, Deborah F.; Kadel, Allison; Aka, Ada; Pedisich, Isaac; Sperling, Michael R.; Sharan, Ashwini; Lega, Bradley C.; Burks, Alexis; Gross, Robert E.; Inman, Cory S.; Jobst, Barbara C.; Gorenstein, Mark A.; Davis, Kathryn A.; Worrell, Gregory A.; Kucewicz, Michal T.; Stein, Joel M.; Gorniak, Richard; Das, Sandhitsu R.; Rizzuto, Daniel S.; and Kahana, Michael J., "Closed-loop stimulation of temporal cortex rescues functional networks and improves memory." (2018). Department of Neurology Faculty Papers. Paper 151.
https://jdc.jefferson.edu/neurologyfp/151
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
29410414
Language
English
Comments
This article has been peer reviewed. It is the author’s final published version in Nature Communications
Volume 9, Issue1, February 2018, Article number 365.
The published version is available at https://doi.org/10.1038/s41467-017-02753-0. Copyright © Ezzyat et al.