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- 126 million Americans reported to have a musculoskeletal or musculotendinous pathology in 20121

- Combined direct and indirect cost of these injuries in 2015 was $874 billion1

- Corticosteroid injections have been the mainstay of invasive management after conservative methods fail
Long-term effects of corticosteroids

  • Intra-articular injections for knee osteoarthritis resulted in cartilage volume loss10
  • Harm to flexor tendons, neurovascular structures, and compromised integrity7, 11

- Platelet Rich Plasma

  • Sample patient blood --> Centrifuge --> Separate plasma and platelets from other blood products --> Reconcentrate the platelets into the plasma
  • Platelets release growth factor beta, vascular endothelial growth factor, platelet derived growth factor, transforming growth factor12, 13
  • Reproduction of cells and regeneration of tissue
  • New application in the management of musculoskeletal and musculotendinous pathologies

- The goal of this literature review is to discuss possible improved outcomes and patient satisfaction when combining platelet rich plasma with corticosteroids in the management of musculoskeletal and musculotendinous pathologies in adults 18 years or older, versus the use of PRP or corticosteroid injections alone.

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platelet rich plasma, corticosteroid, corticosteroid injection, PRP


Medicine and Health Sciences | Pathology


Capstone presentations were completed in partial fulfillment of the Master of Science degree in Physician Assistant Studies at Thomas Jefferson University.

Document Type


The Combination of Platelet Rich Plasma and Corticosteroids in Musculoskeletal and Musculotendinous Pathologies

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Pathology Commons