Title

The Combination of Platelet Rich Plasma and Corticosteroids in Musculoskeletal and Musculotendinous Pathologies

Authors

Mikayla Stoudt, Thomas Jefferson UniversityFollow

Files

Description

Background

- 126 million Americans reported to have a musculoskeletal or musculotendinous pathology in 2012¹

- Combined direct and indirect cost of these injuries in 2015 was $874 billion¹

- Corticosteroid injections have been the mainstay of invasive management after conservative methods fail
Long-term effects of corticosteroids

• Intra-articular injections for knee osteoarthritis resulted in cartilage volume loss¹⁰
• Harm to flexor tendons, neurovascular structures, and compromised integrity^{7, 11}

- Platelet Rich Plasma

• Sample patient blood --> Centrifuge --> Separate plasma and platelets from other blood products --> Reconcentrate the platelets into the plasma
• Platelets release growth factor beta, vascular endothelial growth factor, platelet derived growth factor, transforming growth factor^{12, 13}
• Reproduction of cells and regeneration of tissue
• New application in the management of musculoskeletal and musculotendinous pathologies

- The goal of this literature review is to discuss possible improved outcomes and patient satisfaction when combining platelet rich plasma with corticosteroids in the management of musculoskeletal and musculotendinous pathologies in adults 18 years or older, versus the use of PRP or corticosteroid injections alone.

Publication Date

8-16-2023

Keywords

platelet rich plasma, corticosteroid, corticosteroid injection, PRP

Disciplines

Medicine and Health Sciences | Pathology

Comments

Capstone presentations were completed in partial fulfillment of the Master of Science degree in Physician Assistant Studies at Thomas Jefferson University.

Document Type

Poster

Recommended Citation

Stoudt, Mikayla, "The Combination of Platelet Rich Plasma and Corticosteroids in Musculoskeletal and Musculotendinous Pathologies" (2023). Master of Science in Physician Assistant Studies Capstone Presentations (Center City). 13.
https://jdc.jefferson.edu/mspas_capstones/13