Defining the Role of Powassan Virus in Evading Host Antiviral Immunity (September 2022)

Authors

Melissa Molho, PhD, Thomas Jefferson UniversityFollow
Holly Ramage, PhD, Thomas Jefferson UniversityFollow

Files

Description

Background

Powassan Virus (POWV) is an emerging neurotropic flavivirus transmitted to humans through the bite of an infected tick. Currently, there is no specific antiviral treatment nor approved vaccine for POWV. During infection, many interferon-independent host proteins and pathways sense and respond to viral infection. Flaviviruses have evolved multiple mechanisms to counteract host antiviral programs, often with individual viral proteins mediating this antagonism. However, it has not been determined if these mechanisms are conserved across diverse flaviviruses.

Publication Date

9-2022

Keywords

Powassan Virus (POWV), innate immunity, tick, flavivirus

Disciplines

Medical Microbiology | Medicine and Health Sciences | Virus Diseases

Comments

Presented at the 16th Jefferson Postdoctoral Research Symposium.

Recommended Citation

Molho, PhD, Melissa and Ramage, PhD, Holly, "Defining the Role of Powassan Virus in Evading Host Antiviral Immunity (September 2022)" (2022). Department of Microbiology and Immunology Posters. 1.
https://jdc.jefferson.edu/miposters/1