Document Type
Article
Publication Date
9-15-2016
Abstract
Human cytomegalovirus (HCMV) is a ubiquitous virus that causes chronic infection and, thus, is one of the most common infectious complications of immune suppression. Adoptive transfer of HCMV-specific T cells has emerged as an effective method to reduce the risk for HCMV infection and/or reactivation by restoring immunity in transplant recipients. However, the CMV-specific CD8(+) T cell response is comprised of a heterogenous mixture of subsets with distinct functions and localization, and it is not clear if current adoptive immunotherapy protocols can reconstitute the full spectrum of CD8(+) T cell immunity. The aim of this review is to briefly summarize the role of these T cell subsets in CMV immunity and to describe how current adoptive immunotherapy practices might affect their reconstitution in patients. The bulk of the CMV-specific CD8(+) T cell population is made up of terminally differentiated effector T cells with immediate effector function and a short life span. Self-renewing memory T cells within the CMV-specific population retain the capacity to expand and differentiate upon challenge and are important for the long-term persistence of the CD8(+) T cell response. Finally, mucosal organs, which are frequent sites of CMV reactivation, are primarily inhabited by tissue-resident memory T cells, which do not recirculate. Future work on adoptive transfer strategies may need to focus on striking a balance between the formation of these subsets to ensure the development of long lasting and protective immune responses that can access the organs affected by CMV disease.
Recommended Citation
Smith, Corinne J; Quinn, Michael; and Snyder, Christopher M, "CMV-Specific CD8 T Cell Differentiation and Localization: Implications for Adoptive Therapies." (2016). Department of Microbiology and Immunology Faculty Papers. Paper 85.
https://jdc.jefferson.edu/mifp/85
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
27695453
Comments
This article has been peer reviewed. It was published in: Frontiers in Immunology.
Volume 7, Issue SEP, 15 September 2016, Article number 352.
The published version is available at DOI: 10.3389/fimmu.2016.00352
Copyright © 2016 Smith, Quinn and Snyder.
This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.
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