Document Type
Article
Publication Date
11-10-2015
Abstract
Cytomegalovirus (CMV) is a herpesvirus that persists for life and maintains extremely large numbers of T cells with select specificities in circulation. However, it is unknown how viral persistence impacts T cell populations in mucosal sites. We found that many murine (M)CMV-specific CD8s in mucosal tissues became resident memory T cells (TRM). These cells adopted an intraepithelial localization in the salivary gland that correlated with, but did not depend on, expression of the integrin CD103. MCMV-specific TRM cells formed early after infection, and spleen-localized cells had reduced capacities to become TRM at late times. Surprisingly, however, small numbers of new TRM cells were formed from the circulating pool throughout infection, favoring populations maintained at high levels in the blood and shifting the immunodominance within the TRM populations over time. These data show that mucosal TRM populations can be dynamically maintained by a persistent infection.
Recommended Citation
Smith, Corinne J; Caldeira-Dantas, Sofia; Turula, Holly; and Snyder, Christopher M., "Murine CMV Infection Induces the Continuous Production of Mucosal Resident T Cells." (2015). Department of Microbiology and Immunology Faculty Papers. Paper 75.
https://jdc.jefferson.edu/mifp/75
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
PubMed ID
26526996
Comments
This article has been peer reviewed. It was published in: Cell Reports.
Volume 13, Issue 6, 10 November 2015, Pages 1137-1148.
The published version is available at DOI: 10.1016/j.celrep.2015.09.076
Copyright © 2015 The Authors