CD27high/KLRG1low CD8+ T cells that persist throughout MCMV infection are highly expansive and have the ability to reestablish MCMV immunity

Authors

Michael Quinn, Thomas Jefferson UniversityFollow
Holly Turula, Thomas Jefferson University
Christopher M. Snyder, Thomas Jefferson UniversityFollow

Document Type

Poster

Publication Date

5-6-2014

Comments

Presented at: AAI 2014, Pittsburgh PA.

Abstract

Abstract

Cytomegalovirus (CMV) is a herpesvirus that establishes life-long latency in 60-80% of Americans. Constant immune surveillance is necessary to prevent viral reactivation from latency and results in the accumulation of functional CMV-specific CD8+ T cells (CD8s) over time, a process termed memory inflation. As such, CMV reactivations remain a clinical concern for immunosuppressed patients and reconstituting CMV immunity is critical for the long-term prevention of CMV disease. Understanding the maintenance of memory inflation may reveal novel approaches to restore CMV immunity.

Previous work has shown that the majority of inflationary CD8s express a terminally-differentiated “effector” (T_EFF) phenotype, have a short half-life and appear unable to sustain long-term CMV immunity. Interestingly, inflationary populations also include a minor subset of CD8s that express a “memory” phenotype (T_M).

Recommended Citation

Quinn, Michael; Turula, Holly; and Snyder, Christopher M., "CD27high/KLRG1low CD8+ T cells that persist throughout MCMV infection are highly expansive and have the ability to reestablish MCMV immunity" (2014). Department of Microbiology and Immunology Faculty Papers. Paper 64.
https://jdc.jefferson.edu/mifp/64