Jefferson Digital Commons

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  Digital Literacy in an Urban Cancer Population: Who Are We Leaving Out?

  A. Petok, MSW, MPH; G. Garber, MSW; L. Waldman, BA; A. Leader, PhD; A. Dicker, MD, PhD; and L. Capparella, MSS

  Background

  • With an increase in and rapid development of health care applications, as well as electronic medical records and patient portals, patients have more access to health information than ever.
  • Previous research has found an association between integration of electronic patient reported outcomes (ePROs) with increased survival for patients with metastatic cancer compared to usual care.
  • Although greater access to health information as well as personal health records and patient portals can be shown to have positive effects on patient outcomes, the digital divide that is pervasive in the general population extends to oncology as well.
  • This project aimed to determine the differences in patient interest in and usage of technology for health care amongst various demographics.

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  Optimizing Psychosocial Care of Older Adults with Cancer: An Early Assessment and Intervention Model

  Lora Rhodes, LCSW and Andrew Chapman, DO, FACP

  Background

  Jefferson Multidisciplinary Senior Adult Oncology Center

  History

  • Established September 2010
  • First multidisciplinary geriatric oncology evaluation center in the tristate area

  Demographics

  • 890 patients evaluated to date
  • All tumor types
  • Age 70 and above & Pre-transplant (Bone Marrow) evaluation age 65 and above

  Format

  • Consultative service
  • Two sessions weekly
  • Average evaluation time: two hours

  Multidisciplinary Team

  • Navigator, Medical Oncologist, Geriatrician, Pharmacist, Nutritionist, Social Worker
  • As needed: Psychiatry, Rehab Medicine, Radiation Oncology, Surgery

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  Exploring the Role of Life Review Videos with Patients Diagnosed with Advanced Cancer

  Lisa M. Capparella, MSS, LCSW, OSW-C and S. Otis-Green, MSW, MA, ACSW, LCSW, OSW-C

  Background/Rationale

  • Life Review Videos can provide patients with hope, help them finding meaning and value of life.
  • Patients with cancer have limited opportunities to discuss their life before cancer.
  • Insufficient research related to how patients would want their video to be used by family/friends and who they would chose to share their video with.
  • Limited research regarding whether the relationship with the interviewer matters to participants of life review.

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  Safety of Lobar Hepatic Arterial Embolization in Metastatic Uveal Melanoma Patients with Underlying Gilbert's Disease

  David C. Feldstein, MD; Robert D. Adamo, MD; Carin F. Gonsalves, MD, FSIR; David J. Eschelman, MS, FSIR; Medical Oncology, Thomas Jefferson University Hospital, Philadelphia, PA; and Takami Sato, MD, PhD

  Introduction

  ❖ Uveal melanoma is the most common primary intraocular malignant tumor in adults.

  ❖ Up to half of all patients develop systemic metastases, with liver involvement in >90% of patients.¹

  ❖ Various liver-directed, locoregional therapies (i.e. chemoembolization, immunoembolization, radioembolization, and ablation) have played a significant role in prolonging the lives of patients with metastatic uveal melanoma.²

  ❖ Elevated bilirubin levels are typically considered a relative contraindication for lobar hepatic arterial embolization treatment, given mainly the increased risk of precipitating hepatic failure.

  ❖ Gilbert's syndrome, also known as benign unconjugated hyperbilirubinemia, is a hereditary disorder of bilirubin conjugation. Gilbert’s syndrome leads to elevated levels of serum bilirubin, that do not truly reflect cholestasis or liver failure and therefore should not exclude patients from targeted embolization therapy.³

  Poster presented at: World Conference on Interventional Oncology in Boston MA.

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  Detection of Circulating Tumor Cells in Uveal Melanoma by the Photoacoustic Method

  Ryan M. Weight, Shingo Sato, Masahiro Ohara, Mizue Terai, Michael Mastrangelo, Marlana Orloff, Benjamin Goldschmidt, John Viator, and Takami Sato

  Abstract

  Circulating tumor cells (CTCs) have been shown to be a prognostic marker in breast cancer¹. We hypothesize that circulating melanoma cell (CMC) detection could be utilized in the management of uveal melanoma, including early intervention. Prior methodologies for circulating uveal melanoma cell (CUMC) detection have been fraught with poor sensitivity, limiting their clinical utility². Development of an improved method is necessary to establish the clinical utility of CUMC monitoring. Photoacoustics, also referred to as laser-induced ultrasound, is a novel platform for the detection and capture of CMCs. Photoacoustics uses short duration pulsed light to create ultrasonic acoustic waves in an optically absorbing medium, in this case melanin within melanoma³. As light is absorbed by irradiated chromophores, the optical energy gets converted into kinetic thermal energy trapped within the chromophore and subsequent thermal expansion ensues. Transient thermoelastic expansion of the absorbent cell results in the propagation of ultrasonic acoustic waves which can be detected and analyzed using a piezoelectric response mechanism. In addition, detected CMCs can be isolated by a two-phase flow cell separation technique⁴. Due to the low cost and melanoma specific capabilities of photoacoustics, we evaluated this technology for the purpose of CUMC detection.

  Methods: Cells from uveal melanoma cell line UM002B, established at Thomas Jefferson, were titrated to various cell concentrations and analyzed in a neutral density solution utilizing the photoacoustic method. Uveal melanoma cells of differing concentrations were spiked into isolated healthy donor peripheral blood mononuclear cells (PBMCs) and healthy whole blood samples. PBMC isolates were analyzed for CUMCs.

  Results: CUMCs were successfully quantified by the photoacoustic method including single cell detection. Recovery rates of cultured cells in a neutral density solution approached 25%. Recovery rates for CUMCs in whole blood averaged 10% of expected cell yield (56/540 cells detected) with a higher detection rate at lower cell concentrations. Photoacoustics offers a viable method for the detection of CUMCs with an accuracy that meets or exceeds previously reported CUMC yields. Studies analyzing CUMCs from patients with metastatic disease are ongoing.

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  Metabolic Patterns in Cancer Cells and Tumor Micro-environment in Diffuse Large B¬Cell Lymphoma: Tumor–Stromal Metabolic Coupling

  Mahasweta Gooptu, MD; Alina E. Dulau Florea, MD; Benjamin E. Leiby, PhD; Barbara Pro, MD; John David Sprandio, Jr. MD; Diana Whitaker-Menezes, PhD; Paolo Cotzia, MD; Guldeep Uppal, MD; Jaime Caro, MD; Jerald Z. Gong, MD; and Ubaldo E. Martinez-Outshoorn, MD

  It has previously been suggested that the tumor microenvironment in diffuse large B-cell lymphoma (DLBCL) has prognostic significance. Furthermore, gene expression profiling in DLBCL patients has identified separate subsets with glycolytic and mitochondrial (oxidative phosphorylative) metabolic signatures.

  Glycolytic metabolism forms the basis for FDG PET scans, widely used in staging and response assessment in DLBCL. While many assume that the tumor as a whole is primarily glycolytic, the metabolic patterns of cancer cells (C) and surrounding cancer-associated stromal cells (CAS) remain relatively unknown. We investigated the in situ metabolic patterns of C and CAS cells as well as tumor-associated macrophages (TAM) in DLBCL.

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  Prevalence of health-related quality of life (HRQOL) in Asian Americans

  Hee-Soon Juon, PhD; Frederic Kim, MS; Seon Yoon Chung, MSN; and Sunmin Lee, ScD

  Objectives

  To report the prevalence of Health Related Quality of Life (HRQOL) in foreign-born Asian Americans (AA) and to compare this with the general AA from 2010 BRFSS data.

  To examine the influential factors associated with HRQOL-4 including English proficiency, perceived racial discrimination, smoking, alcohol use, and sociodemographics.

  Background

  Quality of life (QOL) represents individuals’ subjective perception of multidimensional aspects of life including physical, psychological, social and spiritual aspects.

  HRQOL represents the physical and mental health domain of QOL.

  Centers for Disease Control and Prevention (CDC) has been measuring HRQOL to capture people’s overall perceptions about their health; HRQOL has become an important component of health surveillance (U.S. DHHS, 2000).

  While acculturation and racial discrimination have been negatively associated to the number of chronic health conditions and well-being of AA, their influence on HRQOL has not been studied.

  Public surveillance study has typically considered Asian Americans as a single group and little is known about how HRQOL and health-related risk factors vary among foreign-born Asian Americans including Chinese-, Korean-, and Vietnamese- Americans.

  Poster presented at APHA in Chicago Illinois.