Metabolic Patterns in Cancer Cells and Tumor Micro-environment in Diffuse Large B¬Cell Lymphoma: Tumor–Stromal Metabolic Coupling

Authors

Mahasweta Gooptu, MD, Thomas Jefferson UniversityFollow
Alina E. Dulau Florea, MD, Thomas Jefferson UniversityFollow
Benjamin E. Leiby, PhD, Thomas Jefferson University HospitalFollow
Barbara Pro, MD, Mainline Health/Bryn Mawr HospitalFollow
John David Sprandio, Jr. MD, Mainline Health/Bryn Mawr Hospital
Diana Whitaker-Menezes, PhD, Thomas Jefferson UniversityFollow
Paolo Cotzia, MD, Department of Pathology, Anatomy, & Cell Biology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PAFollow
Guldeep Uppal, MD, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson UniversityFollow
Jaime Caro, MD, Thomas Jefferson UniversityFollow
Jerald Z. Gong, MD, Thomas Jefferson UniversityFollow
Ubaldo E. Martinez-Outshoorn, MD, Thomas Jefferson UniversityFollow

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Description

It has previously been suggested that the tumor microenvironment in diffuse large B-cell lymphoma (DLBCL) has prognostic significance. Furthermore, gene expression profiling in DLBCL patients has identified separate subsets with glycolytic and mitochondrial (oxidative phosphorylative) metabolic signatures.

Glycolytic metabolism forms the basis for FDG PET scans, widely used in staging and response assessment in DLBCL. While many assume that the tumor as a whole is primarily glycolytic, the metabolic patterns of cancer cells (C) and surrounding cancer-associated stromal cells (CAS) remain relatively unknown. We investigated the in situ metabolic patterns of C and CAS cells as well as tumor-associated macrophages (TAM) in DLBCL.

Publication Date

12-7-2015

Keywords

Metabolic Patterns in Cancer Cells and Tumor Micro-environment in Diffuse Large B¬Cell Lymphoma, Tumor–Stromal Metabolic Coupling

Disciplines

Oncology

Comments

Poster presented at American Society of Hematology conference in Orlando Florida.

Recommended Citation

Gooptu, MD, Mahasweta; Dulau Florea, MD, Alina E.; Leiby, PhD, Benjamin E.; Pro, MD, Barbara; Sprandio, Jr. MD, John David; Whitaker-Menezes, PhD, Diana; Cotzia, MD, Paolo; Uppal, MD, Guldeep; Caro, MD, Jaime; Gong, MD, Jerald Z.; and Martinez-Outshoorn, MD, Ubaldo E., "Metabolic Patterns in Cancer Cells and Tumor Micro-environment in Diffuse Large B¬Cell Lymphoma: Tumor–Stromal Metabolic Coupling" (2015). Department of Medical Oncology Posters. 2.
https://jdc.jefferson.edu/medoncposters/2