Document Type
Article
Publication Date
7-19-2024
Abstract
BACKGROUND: The association between fibrinogen-to-albumin ratio (FAR) and in-hospital mortality in patients with spontaneous intracerebral hemorrhage (ICH) has been established. However, the association with long-term mortality in spontaneous ICH remains unclear. This study aims to investigate the association between FAR and long-term mortality in these patients.
METHODS: Our retrospective study involved 3,538 patients who were diagnosed with ICH at West China Hospital, Sichuan University. All serum fibrinogen and serum albumin samples were collected within 24 h of admission and participants were divided into two groups according to the FAR. We conducted a Cox proportional hazard analysis to evaluate the association between FAR and long-term mortality.
RESULTS: Out of a total of 3,538 patients, 364 individuals (10.3%) experienced in-hospital mortality, and 750 patients (21.2%) succumbed within one year. The adjusted hazard ratios (HR) showed significant associations with in-hospital mortality (HR 1.61, 95% CI 1.31-1.99), 1-year mortality (HR 1.45, 95% CI 1.25-1.67), and long-term mortality (HR 1.45, 95% CI 1.28-1.64). Notably, the HR for long-term mortality remained statistically significant at 1.47 (95% CI, 1.15-1.88) even after excluding patients with 1-year mortality.
CONCLUSION: A high admission FAR was significantly correlated with an elevated HR for long-term mortality in patients with ICH. The combined assessment of the ICH score and FAR at admission showed higher predictive accuracy for long-term mortality than using the ICH score in isolation.
Recommended Citation
Chen, Shiping; Zhang, Yu; Xiao, Yangchun; Cheng, Xin; Peng, Liyuan; Tian, Yixin; Li, Tiangui; He, Jialing; Hao, Pengfei; Chong, Weelic; Hai, Yang; You, Chao; and Fang, Fang, "Association of High Fibrinogen to Albumin Ratio With Long-Term Mortality in Patients With Spontaneous Intracerebral Hemorrhage" (2024). Department of Medical Oncology Faculty Papers. Paper 272.
https://jdc.jefferson.edu/medoncfp/272
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
39099785
Language
English
Included in
Amino Acids, Peptides, and Proteins Commons, Epidemiology Commons, Investigative Techniques Commons, Oncology Commons
Comments
This article, first published by Frontiers Media, is the author's final published version in Frontiers in Neurology, Volume 15, 2024, Article number 1412804.
The published version is available at https://doi.org/10.3389/fneur.2024.1412804.
Copyright © 2024 Chen, Zhang, Xiao, Cheng, Peng, Tian, Li, He, Hao, Chong, Hai, You and Fang