Document Type
Article
Publication Date
9-1-2022
Abstract
Rationale: Few case series have described the simultaneous development of angioedema in patients with coronavirus 19 disease (COVID-19). Most of these reports were described in at-risk patients for developing bradykinin angioedema. Therefore, we aim to describe 5 African American patients who developed simultaneous COVID-19 and angioedema.
Methods: This was a case series of hospitalized patients with simultaneous angioedema and COVID-19 infection in a single center from May 2020 to February 2022. We used descriptive statistics. The study was approved by the institutional review board.
Results: Their median age was 55 years (range 28-66); all patients were African American, and 3/5 were males. All patients developed angioedema within a week of hospitalization. Two subjects had prior history of ACEI-related angioedema but were not exposed to ACEI recently, whereas 1 subject was on chronic lisinopril therapy for the last 3 years. All patients had orofacial involvement; the most common locations were lips (5/5) and tongue (3/5). None had histaminergic features of angioedema (either skin rash or peripheral eosinophilia). 4/5 subjects had respiratory symptoms and chest imaging features of COVID-19 pneumonia, whereas 3/5 subjects developed severe COVID-19 infection. Most patients were treated with standard combination of H1 and H2 blockers, and corticosteroids. A total of 2/5 subjects were intubated; one patient developed refractory tongue swelling, received tracheostomy for extubation, and died due to COVID-19 pneumonia. The median length of angioedema improvement was 44 hours (range 20-168 hours). The median length of hospital stay was 15 days (range 1-49).
Conclusion: We described 5 cases of angioedema in COVID-19 patients that shared risk factors and features of bradykinin-related angioedema.
Recommended Citation
Martinez Manzano, Jose Manuel; Ysea-Hill, Otoniel; Chiang, Brenda; Jarrett, Simone A; Lo, Kevin Bryan; and Azmaiparashvili, Zurab, "Coronavirus Disease-19 Infection and Angioedema in African Americans: A Case Series" (2022). Department of Medicine Faculty Papers. Paper 373.
https://jdc.jefferson.edu/medfp/373
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
PubMed ID
35782753
Language
English
Comments
This article is the author's final published version in Otolaryngology Case Reports, Volume 24, September 2022, Article number 100457.
The published version is available at https://doi.org/10.1016/j.xocr.2022.100457.
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