Document Type
Article
Publication Date
4-15-2013
Abstract
Postnatal maturation of esophageal musculature involves proximal-to-distal replacement of smooth muscle with skeletal muscle by elusive mechanisms. We report that this process is impaired in mice lacking the cell surface receptor Cdo and identify the underlying developmental mechanism. A myogenic transition zone containing proliferative skeletal muscle precursor cells migrated in a proximal-distal direction, leaving differentiated myofibers in its wake. Distal to the transition zone, smooth muscle fascicles underwent a morphogenetic process whereby they changed their orientation relative to each other and to the lumen. Consequently, a path was cleared for the transition zone, and smooth muscle ultimately occupied only the distal-most esophagus; there was no loss of smooth muscle. Cdo(-/-) mice were specifically defective in fascicular reorientation, resulting in an aberrantly proximal skeletal-smooth muscle boundary. Furthermore, Cdo(-/-) mice displayed megaesophagus and achalasia, and their lower esophageal sphincter was resistant to nitric oxide-induced relaxation, suggesting a developmental linkage between patterning and sphincter function. Collectively, these results illuminate mechanisms of esophageal morphogenesis and motility disorders.
Recommended Citation
Romer, Anthony I; Singh, Jagmohan; Rattan, Satish; and Krauss, Robert S, "Smooth muscle fascicular reorientation is required for esophageal morphogenesis and dependent on Cdo." (2013). Department of Medicine Faculty Papers. Paper 111.
https://jdc.jefferson.edu/medfp/111
PubMed ID
23569214
Comments
This article has been peer reviewed. It was published in: Journal of Cell Biology.
Volume 201, Issue 2, 15 April 2013, Pages 309-323.
The published version is available at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628509/. DOI: 10.1083/jcb.201301005
Copyright © 2013 Romer et al.