BACKGROUND: Data regarding outcomes among patients with cancer and co-morbid cardiovascular disease (CVD)/cardiovascular risk factors (CVRF) after SARS-CoV-2 infection are limited.
OBJECTIVES: To compare Coronavirus disease 2019 (COVID-19) related complications among cancer patients with and without co-morbid CVD/CVRF.
METHODS: Retrospective cohort study of patients with cancer and laboratory-confirmed SARS-CoV-2, reported to the COVID-19 and Cancer Consortium (CCC19) registry from 03/17/2020 to 12/31/2021. CVD/CVRF was defined as established CVD
RESULTS: Among 10,876 SARS-CoV-2 infected patients with cancer (median age 65 [IQR 54-74] years, 53% female, 52% White), 6253 patients (57%) had co-morbid CVD/CVRF. Co-morbid CVD/CVRF was associated with higher COVID-19 severity (adjusted OR: 1.25 [95% CI 1.11-1.40]). Adverse CV events were significantly higher in patients with CVD/CVRF (all
CONCLUSIONS: Co-morbid CVD/CVRF is associated with higher COVID-19 severity among patients with cancer, particularly those not receiving active cancer therapy. While infrequent, COVID-19 related CV complications were higher in patients with comorbid CVD/CVRF. (COVID-19 and Cancer Consortium Registry [CCC19]; NCT04354701).
Moey, Melissa Y.Y.; Hennessy, Cassandra; French, Benjamin; Warner, Jeremy L.; Tucker, Matthew D.; Hausrath, Daniel J.; Shah, Dimpy P.; DeCara, Jeanne M.; Bakouny, Ziad; Labaki, Chris; Choueiri, Toni K.; Dent, Susan; Akhter, Nausheen; Ismail-Khan, Roohi; Tachiki, Lisa; Slosky, David; Polonsky, Tamar S.; Awosika, Joy A.; Crago, Audrey; Wise-Draper, Trisha; Balanchivadze, Nino; Hwang, Clara; Fecher, Leslie A.; Gomez, Cyndi Gonzalez; Hayes-Lattin, Brandon; Glover, Michael J.; Shah, Sumit A.; Gopalakrishnan, Dharmesh; Griffiths, Elizabeth A.; Kwon, Daniel H.; Koshkin, Vadim S.; Mahmood, Sana; Bashir, Babar; Nonato, Taylor; Razavi, Pedram; McKay, Rana R.; Nagaraj, Gayathri; Oligino, Eric; Puc, Matthew; Tregubenko, Polina; Wulff-Burchfield, Elizabeth M.; Xie, Zhuoer; Halfdanarson, Thorvardur R.; Farmakiotis, Dimitrios; Klein, Elizabeth J.; Robilotti, Elizabeth V.; Riely, Gregory J.; Durand, Jean-Bernard; Hayek, Salim S.; Kondapalli, Lavanya; Berg, Stephanie; O'Connor, Timothy E.; Bilen, Mehmet A.; Castellano, Cecilia; Accordino, Melissa K.; Sibel, Blau; Weissmann, Lisa B.; Jani, Chinmay; Flora, Daniel B.; Rudski, Lawrence; Dutra, Miriam Santos; Nathaniel, Bouganim; Ruíz-García, Erika; Vilar-Compte, Diana; Gupta, Shilpa; Morgans, Alicia; and Nohria, Anju, "COVID-19 Severity and Cardiovascular Outcomes in SARS-CoV-2-Infected Patients With Cancer and Cardiovascular Disease" (2023). Kimmel Cancer Center Faculty Papers. Paper 107.
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