Correspondence Between Perceived Pubertal Development and Hormone Levels in 9-10 Year-Olds From the Adolescent Brain Cognitive Development Study.

Authors

• Megan M Herting, Preventive Medicine, University of Southern California, Los Angeles, CA, United States, Department of Pediatrics, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, United States
• Kristina A Uban, Public Health, University of California, Irvine, Irvine, CA, United States; Institute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, Irvine, CA, United States
• Marybel Robledo Gonzalez, Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States; Research on Children, Youth, and Families, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, United States
• Fiona C Baker, Center for Health Sciences, SRI International, Menlo Park, CA, United States
• Eric C Kan, Department of Pediatrics, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, United States; Research on Children, Youth, and Families, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, United States
• Wesley K Thompson, Division of Biostatistics, University of California, San Diego, La Jolla, CA, United States
• Douglas A Granger, Institute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, Irvine, CA, United States; Social Ecology, University of California, Irvine, Irvine, CA, United States; Bloomberg School of Public Health, Johns Hopkins University, Baltimore, CA, United States
• Matthew D Albaugh, Preventive Medicine, University of Southern California, Los Angeles, CA, United States
• Andrey P Anokhin, Department of Psychiatry, Washington University, St. Louis, MO, United States
• Kara S Bagot, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States
• Marie T Banich, Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States
• Deanna M Barch, Department of Psychological and Brain Sciences, Washington University, St. Louis, MO, United States
• Arielle Baskin-Sommers, Department of Psychology, University of Yale, New Haven, CT, United States
• Florence J Breslin, Laureate Institute for Brain Research, Tulsa, OK, United States
• B J Casey, Department of Psychology, University of Yale, New Haven, CT, United States
• Bader Chaarani, Department of Psychiatry, University of Vermont, Burlington, VT, United States
• Linda Chang, Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD, United States
• Duncan B Clark, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States
• Christine C Cloak, Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD, United States
• R Todd Constable, Radiology and Biomedical Imaging, University of Yale, New Haven, CT, United States
• Linda B Cottler, Department of Epidemiology, University of Florida, Gainesville, FL, United States
• Rada K Dagher, Division of Scientific Programs, National Institute on Minority Health and Health Disparities, Bethesda, MD, United States
• Mirella Dapretto, Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, United States
• Anthony S Dick, Department of Psychology, Florida International University, Miami, FL, United States
• Nico Dosenbach, Department of Neurology, Washington University, St. Louis, MO, United States
• Gayathri J Dowling, Division of Extramural Research, National Institute on Drug Abuse, Bethesda, MD, United States
• Julie A Dumas, Department of Psychiatry, University of Vermont, Burlington, VT, United States
• Sarah Edwards, Department of Psychiatry, University of Maryland, Baltimore, MD, United States
• Thomas Ernst, Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD, United States
• Damien A Fair, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States
• Sarah W Feldstein-Ewing, Department of Psychology, University of Rhode Island, Kingston, RI, United States
• Edward G Freedman, Department of Neuroscience, University of Rochester, Rochester, NY, United States
• Bernard F Fuemmeler, Health Behavior and Policy, Virginia Commonwealth University, Richmon, VA, United States
• Hugh Garavan, Department of Psychiatry, University of Vermont, Burlington, VT, United States
• Dylan G Gee, Department of Psychology, University of Yale, New Haven, CT, United States
• Jay N Giedd, Department of Psychiatry, University of San Diego, La Jolla, CA, United States
• Paul E A Glaser, Department of Psychiatry, Washington University, St. Louis, MO, United States
• Aimee Goldstone, Center for Health Sciences, SRI International, Menlo Park, CA, United States
• Kevin M Gray, Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States
• Samuel W Hawes, Department of Psychology, Florida International University, Miami, FL, United States
• Andrew C Heath, Department of Psychiatry, Washington University, St. Louis, MO, United States
• Mary M Heitzeg, Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States
• John K Hewitt, Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States
• Charles J Heyser, Center for Human Development, University of California, San Diego, La Jolla, CA, United States
• Elizabeth A Hoffman, Division of Extramural Research, National Institute on Drug Abuse, Bethesda, MD, United States
• Rebekah S Huber, Department of Psychiatry, University of Utah, Salt Lake City, UT, United States
• Marilyn A. Huestis, Medical Cannabis & Science Program, Thomas Jefferson University, Philadelphia, PA, United StatesFollow
• Luke W Hyde, Department of Psychology, University of Michigan, Ann Arbor, MI, United States
• M Alejandra Infante, Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States
• Masha Y Ivanova, Preventive Medicine, University of Southern California, Los Angeles, CA, United States
• Joanna Jacobus, Department of Psychiatry, University of San Diego, La Jolla, CA, United States
• Terry L Jernigan, Department of Cognitive Science, University of San Diego, La Jolla, CA, United States
• Nicole R Karcher, Department of Psychiatry, Washington University, St. Louis, MO, United States
• Angela R Laird, Department of Physics, Florida International University, Miami, FL, United States
• Kimberly H LeBlanc, Division of Extramural Research, National Institute on Drug Abuse, Bethesda, MD, United States
• Krista Lisdahl, Department of Psychology, University of Wisconsin, Milwaukee, WI, United States
• Monica Luciana, Department of Psychology, University of Minnesota, Minneapolis, MN, United States
• Beatriz Luna, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States
• Hermine H Maes, Human & Molecular Genetics, Virginia Commonwealth University, Richmond, VT, United States
• Andrew T Marshall, Department of Pediatrics, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, United States; Department of Pediatrics, University of Southern California, Los Angeles, CA, United States
• Michael J Mason, Center for Behavioral Health Research, University of Tennessee, Knoxville, TN, United States
• Erin C McGlade, Department of Psychiatry, University of Utah, Salt Lake City, UT, United States
• Amanda S Morris, Laureate Institute for Brain Research, Tulsa, OK, United States; Human Development and Family Science, Oklahoma State University, Tulsa, OK, United States
• Bonnie J Nagel, Department of Psychiatry, Oregon Health & Science University, Portland, OR, United States
• Gretchen N Neigh, Anatomy & Neurobiology, Virginia Commonwealth University, Richmond, VT, United States
• Clare E Palmer, Center for Human Development, University of California, San Diego, La Jolla, CA, United States
• Martin P Paulus, Laureate Institute for Brain Research, Tulsa, OK, United States
• Alexandra S Potter, Department of Psychiatry, University of Vermont, Burlington, VT, United States
• Leon I Puttler, Department of Psychiatry, University of Vermont, Burlington, VT, United States
• Nishadi Rajapakse, Division of Scientific Programs, National Institute on Minority Health and Health Disparities, Bethesda, MD, United States
• Kristina Rapuano, Department of Psychology, University of Yale, New Haven, CT, United States
• Gloria Reeves, Department of Psychiatry, University of Maryland, Baltimore, MD, United States
• Perry F Renshaw, Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, United States
• Claudiu Schirda, Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States
• Kenneth J Sher, Department of Psychology, University of Missouri, Columbia, MO, United States
• Chandni Sheth, Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, United States
• Paul D Shilling, Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States
• Lindsay M Squeglia, Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States
• Matthew T Sutherland, Department of Psychology, Florida International University, Miami, FL, United States
• Susan F Tapert, Department of Pediatrics, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, United States
• Rachel L Tomko, Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States
• Deborah Yurgelun-Todd, Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, United States
• Natasha E Wade, Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States
• Susan R B Weiss, Division of Extramural Research, National Institute on Drug Abuse, Bethesda, MD, United States
• Robert A Zucker, Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States
• Elizabeth R Sowell, Research on Children, Youth, and Families, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, United States

Document Type

Article

Publication Date

2-18-2021

Comments

This article, first published in Frontiers in Endocrinology, is the author's final published version in Frontiers in Endocrinology, Volume 11, February 2021, Article number 549928.

The published version is available at https://doi.org/10.3389/fendo.2020.549928.

Copyright © 2021 Herting, Uban, Gonzalez, Baker, Kan, Thompson, Granger, Albaugh, Anokhin, Bagot, Banich, Barch, Baskin-Sommers, Breslin, Casey, Chaarani, Chang, Clark, Cloak, Constable, Cottler, Dagher, Dapretto, Dick, Dosenbach, Dowling, Dumas, Edwards, Ernst, Fair, Feldstein-Ewing, Freedman, Fuemmeler, Garavan, Gee, Giedd, Glaser, Goldstone, Gray, Hawes, Heath, Heitzeg, Hewitt, Heyser, Hoffman, Huber, Huestis, Hyde, Infante, Ivanova, Jacobus, Jernigan, Karcher, Laird, LeBlanc, Lisdahl, Luciana, Luna, Maes, Marshall, Mason, McGlade, Morris, Nagel, Neigh, Palmer, Paulus, Potter, Puttler, Rajapakse, Rapuano, Reeves, Renshaw, Schirda, Sher, Sheth, Shilling, Squeglia, Sutherland, Tapert, Tomko, Yurgelun-Todd, Wade, Weiss, Zucker and Sowell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Abstract

Aim: To examine individual variability between perceived physical features and hormones of pubertal maturation in 9-10-year-old children as a function of sociodemographic characteristics.

Methods: Cross-sectional metrics of puberty were utilized from the baseline assessment of the Adolescent Brain Cognitive Development (ABCD) Study—a multi-site sample of 9–10 year-olds (n = 11,875)—and included perceived physical features via the pubertal development scale (PDS) and child salivary hormone levels (dehydroepiandrosterone and testosterone in all, and estradiol in females). Multi-level models examined the relationships among sociodemographic measures, physical features, and hormone levels. A group factor analysis (GFA) was implemented to extract latent variables of pubertal maturation that integrated both measures of perceived physical features and hormone levels.

Results: PDS summary scores indicated more males (70%) than females (31%) were prepubertal. Perceived physical features and hormone levels were significantly associated with child's weight status and income, such that more mature scores were observed among children that were overweight/obese or from households with low-income. Results from the GFA identified two latent factors that described individual differences in pubertal maturation among both females and males, with factor 1 driven by higher hormone levels, and factor 2 driven by perceived physical maturation. The correspondence between latent factor 1 scores (hormones) and latent factor 2 scores (perceived physical maturation) revealed synchronous and asynchronous relationships between hormones and concomitant physical features in this large young adolescent sample.

Conclusions: Sociodemographic measures were associated with both objective hormone and self-report physical measures of pubertal maturation in a large, diverse sample of 9-10 year-olds. The latent variables of pubertal maturation described a complex interplay between perceived physical changes and hormone levels that hallmark sexual maturation, which future studies can examine in relation to trajectories of brain maturation, risk/resilience to substance use, and other mental health outcomes.

Recommended Citation

Herting, Megan M; Uban, Kristina A; Gonzalez, Marybel Robledo; Baker, Fiona C; Kan, Eric C; Thompson, Wesley K; Granger, Douglas A; Albaugh, Matthew D; Anokhin, Andrey P; Bagot, Kara S; Banich, Marie T; Barch, Deanna M; Baskin-Sommers, Arielle; Breslin, Florence J; Casey, B J; Chaarani, Bader; Chang, Linda; Clark, Duncan B; Cloak, Christine C; Constable, R Todd; Cottler, Linda B; Dagher, Rada K; Dapretto, Mirella; Dick, Anthony S; Dosenbach, Nico; Dowling, Gayathri J; Dumas, Julie A; Edwards, Sarah; Ernst, Thomas; Fair, Damien A; Feldstein-Ewing, Sarah W; Freedman, Edward G; Fuemmeler, Bernard F; Garavan, Hugh; Gee, Dylan G; Giedd, Jay N; Glaser, Paul E A; Goldstone, Aimee; Gray, Kevin M; Hawes, Samuel W; Heath, Andrew C; Heitzeg, Mary M; Hewitt, John K; Heyser, Charles J; Hoffman, Elizabeth A; Huber, Rebekah S; Huestis, Marilyn A.; Hyde, Luke W; Infante, M Alejandra; Ivanova, Masha Y; Jacobus, Joanna; Jernigan, Terry L; Karcher, Nicole R; Laird, Angela R; LeBlanc, Kimberly H; Lisdahl, Krista; Luciana, Monica; Luna, Beatriz; Maes, Hermine H; Marshall, Andrew T; Mason, Michael J; McGlade, Erin C; Morris, Amanda S; Nagel, Bonnie J; Neigh, Gretchen N; Palmer, Clare E; Paulus, Martin P; Potter, Alexandra S; Puttler, Leon I; Rajapakse, Nishadi; Rapuano, Kristina; Reeves, Gloria; Renshaw, Perry F; Schirda, Claudiu; Sher, Kenneth J; Sheth, Chandni; Shilling, Paul D; Squeglia, Lindsay M; Sutherland, Matthew T; Tapert, Susan F; Tomko, Rachel L; Yurgelun-Todd, Deborah; Wade, Natasha E; Weiss, Susan R B; Zucker, Robert A; and Sowell, Elizabeth R, "Correspondence Between Perceived Pubertal Development and Hormone Levels in 9-10 Year-Olds From the Adolescent Brain Cognitive Development Study." (2021). Institute of Emerging Health Professions Faculty Papers. Paper 9.
https://jdc.jefferson.edu/iehpfp/9

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

Language

English