Intrahepatic Cholangiocarcinoma Presenting as LI-RADS 5 "HCC"

Authors

Raja K. Dhanekula, MD, Division of Gastroenterology and Hepatology, Thomas Jefferson University HospitalFollow
Donald Mitchell, MD, Department of Radiology, Thomas Jefferson UniversityFollow
John Farber, MD, Center for Translational Medicine, Cardiology Division, Thomas Jefferson UniversityFollow
Ashwin R. Sama, MD, Department of Medical Oncology, Thomas Jefferson UniversityFollow
Jesse M. Civan, MD, Division of Gastroenterology and Hepatology, Thomas Jefferson University HospitalFollow

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Description

Background

• Hepatocellular Carcinoma (HCC), if within Milan Criteria, is an indication for liver transplantation.

• In contrast, intrahepatic cholangiocarcinoma (IHCC) is a contra-indication to liver transplantation due to high rates of recurrence.

• LI-RADS 5 classification (synonymous with OPTN-5) carries a near 100% positive predictive value for HCC, allowing prioritization of patients for liver transplantation without histological confirmation.

• The “LI-RADS M” classification indicates the presence of malignancy not meeting diagnostic criteria for HCC. In theory, IHCC lesions should be identified as LI-RADS M and not LI-RADS 5.

Publication Date

11-13-2016

Disciplines

Gastroenterology | Hepatology | Oncology | Pathology | Radiology

Comments

Poster presented at AASLD annual meeting in Boston MA.

Recommended Citation

Dhanekula, MD, Raja K.; Mitchell, MD, Donald; Farber, MD, John; Sama, MD, Ashwin R.; and Civan, MD, Jesse M., "Intrahepatic Cholangiocarcinoma Presenting as LI-RADS 5 "HCC"" (2016). Division of Gastroenterology and Hepatology Posters.
https://jdc.jefferson.edu/gastrohepposters/3