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This article has been peer reviewed. It is the authors' final version prior to publication in Gastroenterology.

Volume 145, Issue 6, December 2013, Pages 1494-5.

The published version is available at DOI:10.1053/j.gastro.2013.07.055. Copyright © Elsevier Inc.


Dear Sir:

We have read with great interest a recent article by Dr. He et al. in the June issue of Gastroenterology.1 The studies provide strong evidence in favor of the concept that smooth muscle–specific myosin phosphatase target subunit 1 (MYPT1) of myosin light chain phosphatase (MLCP) plays a critical role in the agonist-induced contraction/relaxation of the smooth muscle. This was shown in their studies using animals with knocked out MYPT1-/-. The investigators employed the Cre-loxP system in which they used the promoter region and exon 1 of Mypt1 flanked by 2 loxP sites to establish Mypt1-floxed mice. These mice were crossed with SMA-Cre transgenic mice to generate smooth muscle–specific MYPT1 knockout mice (Mypt1SMKO).

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