Smooth Muscle-Specific Myosin Phosphatase Target Subunit 1 (MYPT1): An Important Piece of the Puzzle.

Authors

Satish Rattan, Thomas Jefferson UniversityFollow

Document Type

Editorial

Publication Date

12-1-2013

Comments

This article has been peer reviewed. It is the authors' final version prior to publication in Gastroenterology.

Volume 145, Issue 6, December 2013, Pages 1494-5.

The published version is available at DOI:10.1053/j.gastro.2013.07.055. Copyright © Elsevier Inc.

Abstract

Dear Sir:

We have read with great interest a recent article by Dr. He et al. in the June issue of Gastroenterology.¹ The studies provide strong evidence in favor of the concept that smooth muscle–specific myosin phosphatase target subunit 1 (MYPT1) of myosin light chain phosphatase (MLCP) plays a critical role in the agonist-induced contraction/relaxation of the smooth muscle. This was shown in their studies using animals with knocked out MYPT1^-/-. The investigators employed the Cre-loxP system in which they used the promoter region and exon 1 of Mypt1 flanked by 2 loxP sites to establish Mypt1-floxed mice. These mice were crossed with SMA-Cre transgenic mice to generate smooth muscle–specific MYPT1 knockout mice (Mypt1^SMKO).

Recommended Citation

Rattan, Satish, "Smooth Muscle-Specific Myosin Phosphatase Target Subunit 1 (MYPT1): An Important Piece of the Puzzle." (2013). Division of Gastroenterology and Hepatology Faculty Papers. Paper 24.
https://jdc.jefferson.edu/gastro_hepfp/24

PubMed ID

24172015