Document Type
Article
Publication Date
10-27-2023
Abstract
Although the past two decades have produced exciting discoveries in the genetics and pathology of amyotrophic lateral sclerosis (ALS), progress in developing an effective therapy remains slow. This review summarizes the critical discoveries and outlines the advances in disease characterization, diagnosis, imaging, and biomarkers, along with the current status of approaches to ALS care and treatment. Additional knowledge of the factors driving disease progression and heterogeneity will hopefully soon transform the care for patients with ALS into an individualized, multi-prong approach able to prevent disease progression sufficiently to allow for a dignified life with limited disability.
Recommended Citation
Ilieva, Hristelina; Vullaganti, Mithila; and Kwan, Justin, "Advances in molecular pathology, diagnosis, and treatment of amyotrophic lateral sclerosis." (2023). Farber Institute for Neuroscience Faculty Papers. Paper 56.
https://jdc.jefferson.edu/farberneursofp/56
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
PubMed ID
37890889
Language
English
Comments
This article is the author's final published version in BMJ, 2023, e075037.
The published version is available at https://doi.org/10.1136/bmj-2023-075037.
Copyright © © Author(s) (or their employer(s)) 2019.