Document Type
Article
Publication Date
7-31-2018
Abstract
Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemical therapy increase patient mortality. Therefore, it is both urgent and important to identify biomarkers facilitating early identification and novel agents preventing recurrence. Accumulating evidence demonstrates that epigenetic aberrations (particularly histone modifications) are crucial in tumor initiation and development. Histone acetylation and methylation are respectively regulated by acetyltransferases-deacetylases and methyltransferases-demethylases, both of which are implicated in ovarian cancer pathogenesis. In this review, we summarize the most recent discoveries pertaining to ovarian cancer development arising from the imbalance of histone acetylation and methylation, and provide insight into novel therapeutic interventions for the treatment of ovarian carcinoma.
Recommended Citation
Yang, Qilian; Yang, Yuqing; Zhou, Nianxin; Tang, Kexin; Lau, Wayne Bond; Lau, Bonnie; Wang, Wei; Xu, Lian; Yang, Zhengnan; Huang, Shuang; Wang, Xin; Yi, Tao; Zhao, Xia; Wei, Yuquan; Wang, Hongjing; Zhao, Linjie; and Zhou, Shengtao, "Epigenetics in ovarian cancer: premise, properties, and perspectives." (2018). Department of Emergency Medicine Faculty Papers. Paper 77.
https://jdc.jefferson.edu/emfp/77
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
30064416
Language
English
Included in
Obstetrics and Gynecology Commons, Oncology Commons, Surgery Commons
Comments
This article has been peer reviewed. It is the author’s final published version in Molecular Cancer, Volume 17, Issue 1, July 2018, Article number 109.
The published version is available at https://doi.org/10.1186/s12943-018-0855-4. Copyright © Yang et al.