Document Type
Article
Publication Date
11-24-2016
Abstract
Long noncoding RNAs (lncRNAs) are transcribed by genomic regions (exceeding 200 nucleotides in length) that do not encode proteins. While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, lncRNAs control pleiotropic cancer phenotypes through interactions with other cellular molecules including DNA, protein, and RNA. Recent studies have demonstrated that dysregulation of lncRNAs is influential in proliferation, angiogenesis, metastasis, invasion, apoptosis, stemness, and genome instability in colorectal cancer (CRC), with consequent clinical implications. In this review, we explicate the roles of different lncRNAs in CRC, and the potential implications for their clinical application.
Recommended Citation
Yang, Yanfei; Zhao, Linjie; Lei, Lingzi; Lau, Wayne Bond; Lau, Bonnie; Yang, Qilian; Le, Xiaobing; Yang, Huiliang; Wang, Chenlu; Luo, Zhongyue; Xuan, Yu; Chen, Yi; Deng, Xiangbing; Xu, Lian; Feng, Min; Yi, Tao; Zhao, Xia; Wei, Yuquan; and Zhou, Shengtao, "LncRNAs: the bridge linking RNA and colorectal cancer." (2016). Department of Emergency Medicine Faculty Papers. Paper 57.
https://jdc.jefferson.edu/emfp/57
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
PubMed ID
27888635
Comments
This article has been peer reviewed. It is the author’s final published version in Oncotarget
Volume 8, Issue 7, November 2016, Pages 12517-12532.
The published version is available at DOI: 10.18632/oncotarget.13573. Copyright © Yang et al.